Anti-diabetes and anti-obesity: A meta-analysis of different compounds
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2016, Vol 6, Issue 9
Abstract
Diabetes and obesity are chief health crisis and mainly age-related metabolic disorders. Diabetes is the main cause of morbidity and mortality worldwide. Obesity is linked with the progression of diabetes mellitus. High levels of glycerol, fatty acids, enzymes, proinflammatory markers and other obese entities build up insulin resistance in obese persons. The pathology of diabetes involves the dysfunction of β-islet cells of pancreas leading to deficient management of blood glucose level. This study demonstrates the anti-diabetic and anti-obesity effect of plant derived chemicals, some agonists, nutraceuticals, pharmaceutical drugs, some proteins and other compounds from 1998 to 2015. Plant derived from chemicals and other compounds were concluded to control diabetes and obesity by increasing number of glucose transporters, β-islet cells of pancreas, and lipid metabolism enzymes. In this way, the impairment of β-islet cells of pancreas is restored and the serum cholesterol and glucose levels of individuals are lowered. Further approaches are also needed to handle and cure diabetes and obesity.
Preventive and curative effect of methanolic extract of Gardenia gummifera Linn. f. on thioacetamide induced oxidative stress in rats
Objective: To evaluate the antioxidant and antihepatotoxic effect of methanolic extract of Gardenia gummifera Linn. f. root (MEGG) on thioacetamide (TAA) induced oxidative stress in male Wistar rats. Methods: In the prev...
Testicular and epididymal pathology in Yankasa rams experimentally infected with Trypanosoma congolense
Objective: To investigate the pathological effect of experimental Trypanosoma congolense (T. congolense) infection on the testes and epididymis of Yankasa rams. Methods: Nine intact un-castrated rams were obtained and di...
An assessment of infant and child mortality by social group and place of residence in districts of Orissa
Objective: To provide an approximation of infant and child mortality rate for all the districts of Orissa using CEB (Children Ever Born) and CS (Children Survival) data of Census of India, 2001. And to find out the corre...
Correlation of serum paraoxonase activities in known cases of 130 elderly hypertensive South Asian aged 56-64 years - a hospital based study
Objective: To evaluate paraoxonase activity, antioxidant status and lipid peroxidation in hypertensive participants and to address the hypothesis that oxidative modifications of lipids due to hypertension can cause chang...
Therapeutic rationale for low dose doxepin in insomnia patients
Histamine is an excitatory neurotransmitter in central nervous system. It plays an important role in the regulation of the sleep-wake cycle. Antidepressant with sleep-promoting effects, for example, doxepin, promotes sle...