Anti-hyperlipidemic Activity of Thieno – [2, 3-d] - Pyrimidin-4- (3H)-ones
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2011, Vol 4, Issue 4
Abstract
Aim: The present study was aimed to evaluate some newly synthesized thieno – [2, 3-d] - pyrimidin-4- (3H)-ones namely SR-C1 to SR-C12 for their anti-hyperlipidemic activity. Materials and Methods: Anti-hyperlipidemic activity was evaluated using Triton 1339-induced hyperlipedemia in rats as an experimental model. Plasma triglycerides, total cholesterol, HDL-C, LDLC, atherogenic index (AI) and LDL-C/HDL-C ratio were determined to assess the anti-hyperlipidemic activity. Results: SR-C1,SR-C4, SR-C5, SR-C6, SR-C7, SR-C11 and SR-C12 have shown significant antihyperlipidemic activity by decreasing the total cholesterol and triglyceride, LDL-cholesterol, atherogenic index and LDL/HDL ratio (p < 0.001) and by increasing the HDL-Cholesterol (p < 0.001). Conclusion: The findings of the present study clearly demonstrates that methyl, methoxy, chloro, dimethylamino, dimethoxy and trimethoxy functional groups possess cholesterol-suppressive capacities and has an ability to attenuate the accelerated development of atherosclerosis in hypercholesterolemic models. However, hydroxyl and nitro derivatives did not show any hypolipidemic activity.
Authors and Affiliations
Rangappa Srinath| Department of Pharmacology, PES College of Pharmacy, 50 Feet Road, Hanumanthanagar Bangalore, Bangaluru-560050, Karnataka, India, Marikunte Venkataranganna| Connexios Life Sciences Pvt Ltd, Bangalore-560078, Karnataka, India, Janardhan Saravanan| Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore-560050, Karnataka, India
Keywords
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- EP ID EP8824
- DOI 10.3889/MJMS.1857-5773.2011.0189
- Views 318
- Downloads 19
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