Anti-inflammatory Activity of Cucumis sativus L.
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 8, Issue 2
Abstract
Aims: To evaluate the anti-inflammatory activity and acute toxicity of Cucumis sativus L. Study Design: Animal model assays of anti-inflammatory. Place and Duration of Study: Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, 410001, Nigeria between April 2014 and November 2014. Methodology: To evaluate anti-inflammatory activity, test substances that included whole Cucumis sativus L. homogenate were administered to four groups of Wistar rats. A control group received normal saline; a reference group received a standard anti-inflammatory drug, Diclofenac while 2 test groups received whole Cucumis sativus L. fruit homogenate, respectively. Inflammation of the right hind paw of rats was induced by subplantar injection of 0.1 ml of 2% agar-agar suspension and increases in paw volumes, which relate to anti-inflammation, were measured using the volume displacement method. To evaluate the acute toxicity of Cucumis sativus L. fruit homogenate, 20 albino mice grouped into five groups of four mice each with animals were used. Animals in different groups were orally administered with different amount of the whole fruit homogenate. The animals were monitored for dullness, nervousness, uncoordinated movement, and death within 24 hours after administration. Results: Paw volume progressive decreased within 5.5 hours in test groups after administration of Cucumis sativus L. The administered Cucumis sativus L did not induce adverse effects on the mice within the concentration range of 0.5 mL/kg body weight to 5 mL/kg body weight test animals. Conclusion: The whole fruit homogenate of Cucumis sativus L. had anti-inflammatory activity and no dose-dependent side effects.
Authors and Affiliations
Uzuazokaro Mark-Maria Agatemor, Okwesili Fred Chiletugo Nwodo, Chioma Assumpta Anosike
Keywords
Related Articles
- EP ID EP344322
- DOI 10.9734/BJPR/2015/19700
- Views 91
- Downloads 0
Pharmacists’ Perspectives on Self-medication by Patrons of Community Pharmacies in Jos, Nigeria
Self-medication with prescription-only-medicine is an important driver of non-rational use of medicines which is highly prevalent in Nigeria, with implications on patients’ health outcomes. Although high accessibility to...
X-ray Crystal Structure of COX-2 Enzyme as a Tool to Predict Active Sites of Bitter Taste Receptors
This commentary discusses a novel approach to be used in the design of active sites of bitter taste receptors, especially TAS2R14, by using the X-ray crystal structure of the enzyme COX-2 and chemical structures of commo...
Pharmacists Perception of Physicians and Patients Responses towards Suggested Drug Alternative
Objective: This study aims to analyze the perceived responses from physicians and patients towards an alternative drug suggested by pharmacist in a physician prescription and to observe the reasons for rejection from phy...
Factor Affecting Photo and Thermal Stability of Levothyroxine Sodium
The aim of this works is to study the thermal and photo-decomposition of levothyroxine sodium. The effect of light on the stability of the drug in solution was studied under conditions of several parameters (concentratio...
In vitro- In vivo Correlation Studies of Modified Release Tolterodine Tablet Dosage form in Rabbits
Tolterodine is an antimuscarnic drug that is used for sympathetic treatment of urinary incontinence. Tolterodine modified release tablet, was investigated in rabbit for pharmacokinetic and in vitro–in vivo correlation st...