ANTI-INFLAMMATORY ACTIVITY OF IBUPROFEN ESTERS BY TRANSDERMAL DELIVERY
Journal Title: Вісник Одеського національного університету. Біологія - Year 2015, Vol 20, Issue 1
Abstract
The goal of this study was to investigate the anti-inflammatory activity of ibuprofen esters ointment after their transdermal application on the model of carrageenan-induced inflammation in experimental animals. In this paper, we have studied the transdermal delivery of ibuprofen esters with methyl, ethyl, octyl and heptyl radicals. The anti-inflammatory activity was assessed on the basis of inhibition of paw edema induced by the injection of 0.2 ml of 0.2 % solution of carrageenan (an edematogenic agent) into the subplantar region of the hind paw of the rat. The ointments were consisted of PEG -1500 , PEO -400 and 1,2- propylene glycol in the following proportions: 4 : 2: 3 and consisted 5% of ibuprofen esters. For comparison, 5% ibuprofen ointment (cream Dolhit) was used. Paw volumes were measured at the beginning of the experiment with a plethysmometer. As a result of the study, it was shown that the level of anti-inflammatory activity ointment with ibuprofen esters with different length of radical in transdermal delivery was not different from anti-inflammatory activity of the commercial referent drug - ibuprofen ointment and in some cases, were more active. We shown that the transdermal delivery of methyl, ethyl and heptyl esters of ibuprofen reduces the level of white blood cells in the blood of experimental rats to the level of physiological norm at the 4th day, after a significant level increase in the acute phase of inflammation.
Authors and Affiliations
I. A. Kravchenko, B. V. Prystupa, M. V. Kireva, A. O. Kobernik
Keywords
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- EP ID EP311009
- DOI 10.18524/2077-1746.2015.1(36).56933
- Views 114
- Downloads 0
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