Anti-inflammatory activity of lisinopril in albino rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 4
Abstract
Background: Angiotensin II (Ang II) is a product of renin angiotensin aldosterone system. Angiotensin-II regulates vascular tone, stimulates the release of pro-inflammatory cytokines, activates nuclear factor-kappa B, increases oxidant stress and functions as an inflammatory molecule. Lisinopril an angiotensin converting enzyme (ACE) inhibitor act by inhibiting ACE, decreases angiotensinogen II activity. Hence the present was to evaluate the anti-inflammatory activity of lisinopril. Aims and Objectives: To evaluate the anti-inflammatory activity of lisinopril in albino rats. Materials and Methods: Eighteen Wistar albino rats weighing around 150–200 g of either sex were randomly selected from central animal facility and divided into three groups. The control group received normal saline 25 ml/kg, standard group received indomethacin 10 mg/kg and test group received lisinopril (3.6 mg/kg) orally for 6 days. The animals were subjected to carrageenan induced paw oedema and cotton pellet induced granuloma model. Results: Lisinopril significantly decreased the mean paw oedema in carrageenan induced paw oedema when compared to control and in cotton pellet induced granuloma lisinopril decreased the mean granuloma weight when compared to control. Conclusion: Lisinopril showed anti-inflammatory activity when given for 6 consecutive days per orally in albino rats in carrageenan induced paw oedema and cotton pellet induced granuloma model.
Authors and Affiliations
Siddamma Amoghimath, Suresha R N
Keywords
Related Articles
- EP ID EP487717
- DOI 10.5455/njppp.2018.8.0934004112017
- Views 88
- Downloads 0
Urate-lowering effect of Manilkara zapota aqueous leaf extracts in a murine model of hyperuricemia
Background: Hyperuricemia and diseases related to hyperuricemia have been recognized among Filipinos in different countries. Diseases related to hyperuricemia such as gout and increased risks of cardiovascular diseases h...
A rare case report on Glanzmann thrombasthenia
Glanzmann thrombasthenia (GT) is a rare inherited blood clotting disorder characterized by the impaired function of platelets that are essential for proper blood clotting and can lead to prolonged bleeding time. Patient...
Awareness about drug information center among health-care professionals at a tertiary care hospital
Background: Drug literature is vast and interprofessional. It is not easy to keep abreast with current drug information (DI). DI Center (DIC) is a facility specializing in the provision of DI in a suitable format; with d...
Self-medication practices among 2nd year medical students in a rural medical college of Telangana state
Background: Self-medication is a part of self-care, hence responsible use of drugs by physician is vital to prevent their acute and chronic adverse effects. People take medicines with their previous experiences and old p...
Variation in pulmonary function tests parameters in different phases of menstrual cycle in healthy female medical students
Background: Menstrual cycle is a physiological process that occurs in women. It is characterized by periodic vaginal bleeding owing to the shedding of uterine mucosa, which has its own effect on various systems an...