Anti-inflammatory and anti-oxidant activity of Dialium dinklagei Harms. (Leguminosae)
Journal Title: World Journal of Pharmaceutical Sciences - Year 2017, Vol 5, Issue 4
Abstract
Dialium dinklagei is a plant used in the management of pain, arthritis, rheumatism, pulmonary diseases and as a laxative in Ghanaian folklore medicine. However there is no scientific validation of these pharmacological activities. Therefore in this research, the anti-oedematogenic and antioxidant activity of a hydro-ethanolic extract of D. dinklagei was evaluated. In vivo anti-inflammatory activity was done by the carrageenan induced oedema in 7 day old chicks. The antioxidant activity was investigated in vitro by the DPPH radical scavenging and phosphomolybdenum total antioxidant capacity assays. D. dinklagei exhibited a dose-dependent anti-inflammatory activity with ED50 of 10.6 mg/kg body weight compared to diclofenac sodium (ED50 = 4.03 mg/kg body weight). It showed considerable antiradical activity (EC50 = 39.6) and a total antioxidant capacity of 581.58 mg of vitamin C per gram of extract. The phytochemicals tannins, alkaloids and terpenoids present in the plant could be responsible for its anti-inflammatory and antioxidant effects. Thus the present study has given scientific credence to the use of D. dinklagei in ethnomedicine for the management of painful inflammatory conditions
Authors and Affiliations
Isaac Kingsley Amponsah
Keywords
Related Articles
- EP ID EP328299
- DOI -
- Views 100
- Downloads 0
Chemical and Bio-guided Evaluation of Some Natural Resins as Potential Antitumor Agents
Naturally occurring resins have beneficial pharmaceutical and nutraceutical properties. Based on the Ethnopharmacological literature, several species of natural resins used in traditional medicine were collected. In this...
Antibiotic susceptibility of Streptococcus pyogenes and Staphylococcus aureus isolated from Pharyngitis and Tonsillitis patients in Nasiriyah City, Iraq
The present study aimed to isolation and identification and antibiotic susceptibility test for Streptococcus pyogenes and Staphylococcus aureus bacteria isolated from Pharyngitis and Tonsillitis patients. 276 swabs were...
Synthesis, characterization and evaluation of new benzimidazole derivatives
A series of new benzimidazole derivatives have been synthesized by simple condensation (Schiff reaction) reaction between benzimidazole derivatives and substituted aromatic aldehydes. All these compounds were characteriz...
Layered double hydroxides-indomethacin nanohybrids: intercalation, pH influence, stability and release properties
In this work, three pH values (8, 9 and 10) were studied for the insertion of Indomethacin (Indo) molecules into Layered Double Hydroxides (LDHs). The obtained results showed that the LDH materials have been a good stora...
Nanotechnology for Diabetes: A Review
This review article discusses the potential applications of nanoparticles and BioMEMS as drug delivery systems for diabetes treatment. This manuscript discusses polymeric nanoparticles, oral insulin administration using...