Anti-inflammatory and antioxidant activities of <i>cassia fistula linn</i> bark extracts
Journal Title: African Journal of Traditional, Complementary and Alternative Medicines - Year 2005, Vol 2, Issue 1
Abstract
Anti-inflammatory and Antioxidant activities of the aqueous (CFA) and methanolic extracts (CFM) of the [i]Cassia fistula[/i] Linn. bark were assayed in wistar albino rats. The extracts were found to posses significant anti-inflammatory effect in both acute and chronic models. [i]Cassia fistula[/i] bark extracts showed significant radical scavenging by inhibiting lipid peroxidation initiated by CCl[sub]4[/sub] and FeSO4 in rat liver and kidney homogenates. Both extracts exhibited significant antioxidant activity in DPPH, Nitric oxide and Hydroxyl radical induced invitro assay methods. Both extracts showed Dose-Dependent protective effect against lipid peroxidation and free radical generation in liver and kidney homogenates. Further, the acute toxicity study with the extracts showed no sign of toxicity up to a dose level of 2000 mg/ po. Thus it could be concluded that Cassia [i]fistula[/i] bark extracts (CFA & CFM) possess significant anti-inflammatory and anti oxidant properties.
Authors and Affiliations
Raju Ilavarasan, Moni Mallika, Subramanian Venkataraman
Keywords
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