ANTIATHEROSCLEROTIC AND ANTIOXIDANT POTENTIAL OF PETROLEUM ETHER EXTRACT OF PROSOPIS CINERARIA POD IN HYPERCHOLESTEROLEMIC RABBITS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 6
Abstract
Objective: The present study is done to investigate the anti-atherosclerotic efficacy of petroleum ether extract of Prosopis cineraria pod in hypercholesterolemic diet-induced atherosclerosis in rabbits. Methods: Atherosclerosis was induced in rabbits by feeding normal diet supplemented with oral administration of cholesterol (500 mg/kg body weight/day) which was mixed in coconut oil for 15 days. Rabbits were then administered with petroleum ether extract of P. cineraria pod for 45 days (Group III), and another set of the group was treated with standard drug Atorvastatin for 45 days. After the completion of the experimental period, the serum biochemistry and histological analysis of thoracic aorta was done. Along with it lipid peroxidation(LPO) and antioxidant parameters such as catalase (CAT), superoxide dismutase (SOD), and ferric reducing ability of plasma (FRAP) were estimated. Results: There was a significant increase (p≤0.001) in serum total cholesterol (TC), low density lipoprtein (LDL) and triglycerides after cholesterol feeding when compared with the control group (Group I). Antioxidant parameters were altered too with an increased serum LPO while the reduction in CAT, SOD, and FRAP was observed. After the administration of the petroleum ether extract, significant reduction in TC, LDL-C, very low-density lipoprotein -C, and triglyceride was observed as compared to high-fat diet control rabbits. Slightly significant reduction in (p≤0.05) atherosclerotic plaque in the aorta was observed while cardiac LPO was lowered alternatively CAT, SOD, and FRAP levels increased in petroleum ether extract administered rabbits. Conclusion: The outcomes from this study recommend that P. cineraria pod extract has hypocholesterolemic effect thereby controlling atherosclerosis and has potent antioxidant activity which may be responsible for improving the lipid profile.
Authors and Affiliations
NOOPUR JAIPAL , HEERA RAM
FORMULATION AND STABILITY EVALUATION OF ATENOLOL GEL IN TWO DIFFERENT BASES
Objective: The aim of the research about atenolol gel is to formulate and evaluate its stability in hydroxypropyl methylcellulose (HPMC) and Aqupec HV-505 gel base. Methods: Gels were formulated using Acupev HV-505 and...
UTILITY OF ANTIGEN DETECTION TEST AND POLYMERASE CHAIN REACTION IN THE DIFFERENTIATION OF TUBERCULOUS AND NON-TUBERCULOUS MYCOBACTERIA
Objectives: Cultivation and identification of mycobacteria to species level remains difficult and time-consuming. Hence, easy and rapid diagnostic methods are necessary for the differentiation of Mycobacterium tuberculos...
SYNTHESIS, SPECTRAL CHARACTERIZATION, AND ANTIPROLIFERATIVE ACTIVITY OF DISPIROPYRROLIDINES CONTAINING 2-THIOXOTHIAZOLIDIN-4-ONE NUCLEUS
Objective: Spiro compounds are present in nature, endowed with deep biological activities. Heterocyclic compounds with a pyrrolidine scaffold are one of the paradigms of organic chemistry that exhibits a wide variety of...
EVALUATION OF GENOTOXICITY PROFILE OF JASADA BHASMA (A ZINC-BASED MINERAL FORMULATION) IN SWISS ALBINO MICE
  Objective: Genotoxicity is regarded as one of the potential risk factors for causing pathological diseases. It was confirmed that many chemicals have the mutagenic activity which leads to cancer. A compound which int...
ANTICANCER POTENTIAL OF α-MANGOSTIN
Objective: Mangosteen (Garcinia mangostana Linn.) is a tropical fruit originated from South East region. Mangosteen exhibiting a variety of pharmacological activities and is often used for traditional medicine. There are...