Antibacterial and antifungal evaluation of some chalcogen bearing ligands, their transition and nontransition metal complexes
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2015, Vol 3, Issue 3
Abstract
Eight chalcogen bearing compounds, 3-(4-fluorophenyl telluro) propylamine (1), 3-(phenyl telluro)propylammonium acetate salt (2), 3-(phenyl telluro)propylacetamide (3) and α-(phenylseleno) acetic acid (4) (1-4 are ligands), [Ph2Sn(Cl).1](NO3) (5), [Ph3Sn.1](BPh4) (6), [ZnCl2.2] (7) and [CdCl2.2] (8) (5-8 are complexes of 1 & 2) were synthesised and screened for antibacterial activity against Gram-positive bacterial strains of Staphylococcus aureus, Bacillus anthracis and the Gramnegative bacteria Escherchia coli. They were also tested for their antifungal activity against Candida tropicalis, Trichophyton rubrum and Asperegillus niger, by using the disk diffusion technique. Inhibition zones demonstrated that compounds 1–3 showed significant activity, due to the presence of N in the form of amine group however Compound 4 bearing an acidic group, shows higher activity against bacterial strains. Compounds 5–8 (having Sn, Zn and Cd in their framework) showed still higher activities, due to increase in the lipophilicity and easier penetration of the compounds into the outer cell wall of the microorganisms, which causes death due to cell membrane rupturing. Compounds 1–8 were most effective against E. coli (bacterial strains), as the cell wall of Gram-negative strains have thin outer lipid membrane, which is made up of lipopolysaccharides. These compounds showed slightly reduced antifungal activity, because the cell wall of fungi is made up of chitin, which is difficult to cross. It could be concluded, from the obtained results that the biological activity of compounds is essentially determined by the number and nature of the organic groups and central metal ion. The presence of NH2, COOH group as well as metal ion like Sn, Zn, Cd in the compounds leads to higher activity.
Authors and Affiliations
R. SAXENA| School of Studies in Chemistry, Jiwaji University, Gwalior-474011, M.P. India, P. SHARMA| School of Studies in Chemistry, Jiwaji University, Gwalior-474011, M.P. India
Keywords
Related Articles
- EP ID EP15339
- DOI -
- Views 297
- Downloads 11
Health Promoting Effects of Phytochemicals from Brassicaceae: A Review
Over the past several years, natural antioxidants have attracted considerable interest as potential treatment for a wide variety of disease states, including cancer and other causes e.g. chronic inflammatory diseases and...
Occupational stress in female academic staff working in private and public universities
The present study was aimed to compare occupational stress between female academic staff working in private and public universities. The sampling frame for the study comprised 1523 full-time female academic staff working...
Comparative pharmacognostical & pharmaceutical evaluation of Vyaghri haritaki avaleha - an ayurvedic formulation
Ulcerative colitis in 17 yr old girl masquerading as severe anemia: A case report
Ulcerative colitis is a chronic inflammatory disease of unknown etiology. It is localized to the colon and spares the upper gastrointestinal tract. Ulcerative colitis can occur at any age, the peak incidence is among t...
A overview: non-steroidal anti-inflammatory drugs and mechanisms
The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabol...