Antibacterial Effect of Aqueous and Ethanolic Extracts of Humulus Lupulus on Mycobacterium tuberculosis
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 8
Abstract
Background and Objectives: Tuberculosis (TB) infectious disease is caused by intracellular pathogen Mycobacterium tuberculosis and is one of the major health problems throughout the world. Humulus lupulus (hop) is a species of flowering plant of the Cannabaceae family, which have sedative, antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. The aim of this study was to evaluate and compare the antimicrobial properties of aqueous and ethanolic extracts of Humulus lupulus on Mycobacterium tuberculosis. Methods: In this semi-experimental research, the plant extract was produced by cold maceration method, then its MIC and MBC for Mycobacterium tuberculosis, was assessed using serial dilution. Results: The results were indicative of strong antimicrobial activity of aqueous and ethanolic extracts of Humulus lupulus against Mycobacterium tuberculosis. The antimicrobial effect of standard strain C was more than standard strain H37RV; The MIC and MBC levels of aqueous extract of Humulus lupulus on Mycobacterium tuberculosis strains C, were 7.8μg/ml and 15.7μg/ml, respectively. This amount for the ethanol extract of Humulus lupulus, was 15.7μg/ml and 31.2μg/ml, respectively. Conclusion: The findings of this study showed that Humulus lupulus extract can be used as antibacterial agent in development of new drugs for the treatment of tuberculosis infectious disease.
Authors and Affiliations
Behnam Rafiee, Davoud Sadeghi, Sepideh Ghani, Nader Mosavari, Shojaat , Seyed Amir Hosseini
Keywords
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