ANTIBIOTIC SUSCEPTIBILITY PATTERN AND ESBL PREVALENCE IN ESCHERICHIA COLI ISOLATES FROM PUS SAMPLES IN A TERTIARY CARE HOSPITAL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: Escherichia coli is one of the most common etiological agent isolated from various infections. ESBL (Extended spectrum beta lactamase) producing strains of Escherichia coli have become a great therapeutic challenge to the clinicians in managing such infections. The aim and objective of the present study is to find out the antibiotic susceptibility pattern and to assess the prevalence of ESBL producers among the Escherichia coli isolates.Methods: 100 isolates of Escherichia coli from pus samples identified by standard conventional methods were included in the study. Antibiotic sensitivity testing was carried out using the Kirby Bauer’s disc diffusion method. Isolates showing resistance to third generation cephalosporins were subjected to phenotypic confirmatory test to confirm ESBL production. Results: The antibiogram revealed higher susceptibility percentage to Amikacin, Gentamicin and Levofloxacin. Higher resistance rate was noted for Amoxyclav, Ciprofloxacin, Cefotaxime, Ceftazidime and Ertapenem. All the isolates were found to be susceptible to Imipenem and Tigecycline. 36% of the Escherichia coli isolate were detected to be ESBL producers. Conclusion: ESBL producing strains of Escherichia coli will cause therapeutic failure and also contribute to multidrug resistance. Hence routine surveillance for ESBL production and infection control methods should be made mandatory.
Authors and Affiliations
Sandhiya R, Lakshmi Priya R, Esthermary Selvam
Keywords
Related Articles
- EP ID EP578971
- DOI -
- Views 74
- Downloads 0
TOXICOLOGICAL AND PHARMACOLOGICAL ASSESSMENT OF GOLD NANORODS IN NORMAL RATS
Objective: assessment of acute, subchronic and chronic toxicity of pegylated gold nanorods (PEG-gold NRs) in Wistar rats of both sex in three routes of administration {intravenous (IV), intramuscular (IM) and subcutaneou...
EXCIPIENTS COPROCESSING INFLUENCE ON THE INTERACTING VARIABLES THAT AFFECT THE DISINTEGRATION PROPERTIES OF A PARACETAMOL TABLET FORMULATION
Objective: Neem gum (NMG) was coprocessed with lactose (LTC) at different ratios to produce novel binders.Methods: The quantitative individual and interaction effects of formulation variables, nature of the coprocessed b...
ANTITUMOR AND CYTOTOXIC ACTIVITY OF GINGER ESSENTIAL OIL (ZINGIBER OFFICINALE ROSCOE)
Objective: To evaluate the cytotoxicty and antitumor activity of ginger essential oil (GEO).Methods: Cytotoxicity towards Dalton’s Lymphoma Ascites (DLA) and Ehrlich Ascites Carcinoma (EAC) cell lines were evaluated by...
PHARMACOGNOSTIC AND PHYTOCHEMICAL EVALUATION OF TREMA ORIENTALIS LEAF
Trema orientalis (Ulmaceae) is native to India. This tree species has been of interest to researchers because it is a medicinal plant employed in the Indian indigenous system of medicine. Pharmacognostic standardization,...
SPECTRAL STUDIES OF THE INTERACTION BETWEEN SOLIFENACIN SUCCINATE AND HERRING SPERM DNA
Objective: The interaction between solifenacin succinate (SFS) and herring sperm DNA (Hs-DNA) was investigated by using UV–vis and fluorescence spectra at pH 7.4.Methods: The UV-vis and fluorimetric titrations were per...