Antidiabetic Activity of Methanol Extract of Canthium parviflorum Lam. Leaves
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 1
Abstract
The present investigation was carried out to study the antidiabetic activity of the methanol extract from the leaves of Canthium parviflorum Lam. (Family- Rubiaceae) in adult Wistar rats at 100, 200 and 400 mg/kg p.o. respectively using normoglycemic, glucose loaded and alloxan induced hyperglycaemic models. Metformin (250 mg/kg, p.o.) was used as reference standard for the activity comparison. Results of the study revealed significant antidiabetic activity of the methanol extract in a dose dependent manner. The antidiabetic activity showed by the extract may be due to by promoting the insulin release from the undestroyed β-cells or its action may be similar to insulin. Our study supports the folklore claims to its utilization as an antidiabetic medicinal plant and and suggests that leaves possess promising therapeutic activity for the maintenance of diabetes mellitus.
Authors and Affiliations
Rupesh Pingale| Department of Pharmaceutical Sciences, NIMS University, Shobhanagar, Jaipur, India, Ashish kumar Sharma| NIMS Institute of Pharmacy, NIMS University, Shobhanagar, Jaipur, India, Gouri Kumar Dash| Faculty of Pharmacy and Health Sciences, University Kuala Lumpur Royal College of Medicine Perak, 30450 Ipoh, Malaysia
Keywords
Related Articles
- EP ID EP15582
- DOI -
- Views 363
- Downloads 20
A rare case of familial hyperekplexia
Familial hyperekplexiaia a rare autosomal dominant or sporadic disorder characterized by abnormal startle reaction elicited by auditory or somatosensory stimuli. Here we report a 3 months old female child presented wit...
A review on pharmacology and phytochemistry of syzygium cumini
To encourage a disease free healthy life Mother Nature has gifted mankind medicinal plants. The world craves new ideas and looks to the Far East and Asia for inspiration and innovation. There is a wealth of technical dat...
Evaluation of pharmacological potentials of the ethanolic extract of a mushroom (Ganoderma lucidum) grown in FCT
The aim of this research work is to evaluate the pharmacological potentials of the mushroom Ganoderma lucidium grown in Federal Capital Territory Abuja, Nigeria. Phytochemical, antioxidant and antibacterial properties...
Antibacterial and Antioxidant activity of Benincasa hispida using Hydrogen peroxide scavenging model
The seeds of Benincasa hispida commonly known as ash gourd belonging to Cucurbitaceae family is employed as a main ingredient in kusmanda lehyam in Ayurvedic system of medicine. The seeds of Benincasa hispida mashed with...
Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery
Pulsatile release profile is characterized by a lag time followed by rapid and complete drug release. Pulsatile drug delivery systems are classified into time-controlled and site-specific delivery systems. The lag time...