ANTIDIABETIC ACTIVITY OF ROOT OF TERMINALIA CHEBULA ON ALLOXAN INDUCED DIABETIC RAT
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 3
Abstract
The aim of this study was to investigate the Antidiabetic and antihyperlipidemic activities of aqueous and ethanol extracts of roots of Terminalia Chebula in alloxan (ALX) induced diabetic rats. Diabetes was confirmed after 5 days of single intraperitoneal injection of ALX (150 mg/kg) in albino Wister rats. Aqueous and ethanol extracts of roots of Terminalia Chebula (200 and 400 mg/kg) and Glibenclamide (10 mg/kg, p.o.) orally administered daily for 15 days, blood was withdrawn for glucose determination on 0, 1, 10 and 15 days respectively. Five days before the termination of the experiment, the oral glucose tolerance test (OGTT) was performed to assess the glucose tolerance. For this purpose, overnight fasted rats were fed glucose (2 g/kg) orally and blood was collected at 0, 30, 60 and 120 min interval from orbital sinus for glucose estimation. On the15th day, overnight fasted rats were sacrificed and blood was collected for the determination of high density lipoproteins cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC), total glycerides (TG) and total proteins (TP). Aqueous and ethanol extracts of roots of Terminalia Chebula at doses of 200 and 400 mg/kg showed significant reduction is blood glucose, lipid when compared to diabetic control group. We concluded that aqueous and ethanol extracts of roots of Terminalia Chebula possess Antidiabetic and antihyperlipidemic activities. The histopathology study of pancreas was also performed which showed hypoglycemic effect.
Authors and Affiliations
Nasim Akram
Keywords
Related Articles
- EP ID EP675448
- DOI -
- Views 201
- Downloads 0
IN VITRO EFFICACY OF TEMPERATURE AND PRESERVATIVES ON FAST FOOD BACILLI, AND THEIR ANTIBIOTIC SUSCEPTIBILITY PROFILE
Background and Objective: Species within the Bacillus genus are ubiquitous, and cause food infections and intoxications. Bacillus species are however rarely assayed for in convenience foods. Furthermore, consumer health...
ASSESSMENT OF SEVERITY OF DKA IN INTENSIVE CARE UNIT
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the d...
ETIOLOGY AND CLINICAL PROFILE OF COMMUNITY ACQUIRED PNEUMONIA
Background: Community acquired pneumonia (CAP) is major cause of morbidity in adults. The presentation may be varied. Severity of the disease is seen to be more if co-morbid conditions are present, especially chronic lun...
ANTIMICROBIAL EFFECTS OF PROBIOTICS IN HUMAN BREAST MILK
Lactic acid bacteria, Lactobacillus plantarum and Lactobacillus pentosus, were isolated from the breast milk of six healthy breast feeding mothers using MRS agar media and API50CHL kit and the total Lactic Acid Bacteria...
A STUDY ON DRUG SENSITIVITY OF Staphylococcus aureus ISOLATED FROM WASTE WATER OF HOSPITAL ENVIROMENT
The aim of this study to investigate the water sample to find out how many strains of Staphylococcus aureus were contaminating. Different antibiotic means different strains of isolate. Medically important pathogens of St...