Antidiabetic Effect of Pleurotus ostreatus (Jacq.ex Fr) kumm. Mushroom on Alloxan-induced Diabetic Rats.
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 2
Abstract
Antidiabetic effects of ethanolic extract of Pleurotus ostreatus (mushroom) on alloxan-induced diabetic rats was studied. The median lethal dose (LD50) of the extract was determined to be 3,472.14 mgkg-1 and a single dose of 380.0, 760.0 and 1140.0 body weight of the extract were intraperitoneally administered as the treatment dose and the blood glucose levels (BGL) examined for 7 hours and 15 hours (prolonged) at 2 and 4 hours intervals respectively. The extract exhibited significant (p<0.05 and p<0.01) reduction in the blood glucose levels of the albino rats. The extract compared favourably with the standard reference drug (metformin) which all gave their maximum BGL reduction at 5 hours duration. The confirmation of antidiabetic potentials of the Pleurotus ostreatus tuber has been justified in this study as claimed by traditional medicine practitionersin Akwa Ibom State.
Authors and Affiliations
Imoh Johnny| Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria, Joseph Okon| Department of Botany and Ecological Studies, Faculty of Science, University of Uyo, P.M.B. 1017 Uyo, Akwa Ibom State-Nigeria.
Keywords
Related Articles
- EP ID EP13419
- DOI -
- Views 474
- Downloads 25
A study on health profile of geriatric population in an urban slum of bijapur
Background: Advances in medical field have increased the longevity of people by reducing morbidity and mortality to a great extent. With the increase in longevity, problems related to old age have also increased. These...
Development and Validation of Dual Wavelength UV Spectrophotometric Method for simultaneous estimation of Cilnidipine and Olmesartan Medoxomil in Tablet dosage form
A simple and economical dual wavelength spectrophotometric method has been developed for the simultaneous estimation of Cilnidipine and Olmesartan Medoxomil in their tablet dosage form. The principle for dual wavelengt...
Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide
Metformin/Gliclazide niosomes were formulated with span 60 by ether injection method. Three batches MG1-MG3 were prepared in order to study influence of drug polymer ratio on the niosomes formation and in vitro drug re...
In situ gel: A Review
Oral route is technique which is used over a decades. It is most preferred and common technique for oral administration of drug in the body, but due to certain limitation such as absorption of drug, drug targeting to par...
Microscopical evaluation of leaf of Maytenus emarginata
Microscopical investigation was carried out on leaves of Maytenus emarginata (Willd.) Ding Hou belongs to family celastraceae, is an evergreen tree that tolerates various types of stresses of the desert, locally known as...