Antidiabetic effects of Cycas edentata aqueous leaf extract on the blood glucose levels of alloxan-induced diabetic ICR mice (Mus musculus L.)
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 11
Abstract
Background: Diabetes mellitus is ranked among one of the most prevalent diseases in the world conveniently described with increased blood glucose levels. Several drugs have been in the market to control diabetes; however, there are certain side effects that may be more of harm than beneficial. With this, alternative therapeutic options have been sought for the control of the disease. Aims and Objectives: The aim of this study is to evaluate the effects of aqueous extracts of Cycas edentata on the blood glucose levels of alloxan-induced diabetic mice. Materials and Methods: Aqueous leaf extract from C. edentata was administered to imprinting control regions (ICR) mice to determine its effect on blood glucose level. Thirty ICR mice were designated into six groups and were administered with double-distilled water, glimepiride, or the C. edentata aqueous extract. Results: After 28 days of treatment, statistical analysis indicated that the C. edentata extract had antihyperglycemic effect. There was a significant difference between the negative control and each experimental group (positive, low, mid, and high). There was also no significant difference observed between the sham control and the other experimental group (positive, low, mid, and high). Furthermore, ICR mice treated with the C. edentata extract had a significantly lowered cholesterol level compared to the sham group. With the use of hematologic analysis, the hemoglobin level, packed cell volume, total red blood cell count, total white blood cell count, neutrophils, eosinophils, lymphocytes, monocytes, and eosinophil were found to be normal which indicates that C. edentata has no effect in this parameter. Conclusion: These results indicate that C. edentata leaves have antidiabetic property at doses between 250 and 1000 mg/kg bodyweight.
Authors and Affiliations
Elisha Jae V Elardo, Abbie Grace M Olea, Francesca Josephine Sta. Cruz, Gloriana Julia C Teope, Rodel Jonathan S Vitor II
Keywords
Related Articles
- EP ID EP292503
- DOI 10.5455/njppp.2017.7.0726018082017
- Views 122
- Downloads 0
Squatting maneuver - an easy and efficient method to evaluate postural effect on human arterial blood pressure regulation
Background: It is always been never ending process to search for the ideal method for cardiovascular autonomic function tests. However, some considerations of the feasible application of the squatting tests seem justifie...
Development of gel composition and technology based on pyrimidine substance
Background: This work was conducted in the framework of quality by design project involving the production of a pharmaceutical gel. Preliminary work included the identification of the quality target product profiles from...
Comparative study of the efficacy and safety of topical antifungal agents clotrimazole versus sertaconazole in the treatment of tinea corporis/cruris
Background: Tinea corporis is a common dermatophytic infection affecting 22-25% of the world population. Clotrimazole is conventional antifungal drug whereas sertaconazole is newer antifungal claimed to be superior to cl...
Chronomorphological and pressure changes in a sign of aging - pseudoexfoliation of the eye
Background: Pseudoexfoliation (PXE) is an age-related disorder, a risk factor for glaucoma. The aim of this research was to study the chronomorphological and pressure changes in PXE of the eye. Aims and Objectives: To de...
Description of physical fitness, blood glucose, and cholesterol levels of the middle age operational workers in transportation company
Background: Physical fitness (PF) is a key to maintain company productivity. The transportation company has complicated jobs and high physical demand. Aging, obesity, and sedentary lifestyle can decrease PF and work prod...