Antifilarial activity of Methanolic extract of Vitex negundo L. leaves against Setaria cervi filarial parasite.
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
Herbal medicinal practice is well known but largely observed all over the world. Currently available antifilarial drugs Diethylcarbamazine citrate, albandazole, Ivermectin and other combination of drugs are not effective against adult parasite. So adulticidal antifilarial drugs is required to control and management of the disease. In the present investigation, antifilarial activity was assessed for Methanolic extract of Vitex negundo L. Leaves against Setaria cervi filarial parasite. Activity was assessed by the method of motility inhibition and MTT reduction assay with concentrations 0.3-0.006 mgmL-1 for 2 to 24 hrs incubation period respectively, by comparing with control. In motility assay, complete inhibition of motility was observed and in MTT reduction assay which gave >50% reduction for concentrations 0.06, 0.1 and 0.3 mgmL-1 at 10, 6 and 2hrs incubation period respectively in a dose dependent manner (p<0.05). Antifilarial activity given by plant extract was found to be a function at their relative concentrations. Inhibitory concentration (IC50) for the plant extract was found to be 0.049mgmL-1. Vitex negundo L. Leaves Methanolic extract showed significant reduction in adult motility in dose dependent manner contributes to the development of database and isolation of active molecule / principle for novel antifilarial drug candidate. Keywords: Antifilarial activity, methanolic extract, Setaria cervi, Vitex negundo L.
Authors and Affiliations
Keertisheel N Sahare, Vinod Singh
Keywords
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