Antifungal effects of crude extract and fractions of Euphorbia splendida Mobayena gainst Aspergillus niger, Aspergillus fumigatus, Candida albicans and Candida krusei
Journal Title: Journal of Pharmaceutical & Health Sciences - Year 2017, Vol 5, Issue 1
Abstract
The significant decline in infectious diseases was owed to the development of the antibiotic industry. Due to the prevalence of drug-resistant organisms alongside the other problems, scientists have been focused on medicinal plants. Medicinal plants and their antimicrobial components are attractive alternatives to antibiot - ics. In the present project, the antimicrobial effects of methanolic extract and fractions of aerial parts of Euphorbia splendida Mobayen were evaluated against Aspergillus niger, Aspergillus fumigatus, Candida albicans, and Candida krusei. Euphorbia splendida samples were transferred to the laboratory after confirmation. The plant samples were then shadow dried before being ground. Different extracts and fractions were prepared by standard methods. The extracts and fractions were kept under standard conditions until used. The antifungal assessment was performed by standard agar diffusion methods. The concentration of 100 mg/ml of each methanolic, hexanic, chloroformic, and aqueous extract inhibited C. krusei growth (15 mm).The methanolic extracts at 100 mg/ml displayed 15 mm inhibition zone on C. albicans plate. The aqueous extract had inhibition zone of 14 mm, in C. albicans culture at 100 mg/ml. The methanolic extract at 100 mg/ml inhibited A. niger (15 mm). Meanwhile, methanolic extract at the same concentration allowed the growth of A. fumigatus only beyond 13 mm zone. It was concluded that antifungal activities of total extract and fractions of Euphorbia splendida were considerable and more experiments were beneficial for drug development.
Authors and Affiliations
Reza Hosseini Doust, Asie Shojaii, Atefe Taghva
Keywords
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