ANTIFUNGAL POTENTIAL OF QUERCUS INFECTORIA GALLS AGAINST CANDIDA ALBICANS-AN INVITRO STUDY
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2
Abstract
The promising potential of antimicrobial plant derived substances has attracted the attention of pharmaceutical and scientific communities during the last few years. The primary benefit of plant derived medicines is that they are relatively safer than their synthetic counterparts and offer profound therapeutic benefits and more affordable treatment. Quercus infectoria is a small tree or a shrub belonging to the Fagaceae (Quercaceae) family. The Gall of Quercus infectoria is described in detail in ethnobotanical and literature to possess various pharmacological actions such as analgesic, anti- inflammatory, antipyretic, antiseptic, antistomatitis, deodorant, derivative, desiccant, expectorant, germicidal, hypnotic, hypoglycaemic, powerful astringent, sedative, local anesthetic, antiviral, antibacterial, larvicidal and antifungal activities. The main constituents found in the galls of Q. infectoria are tannin (50-70%) and small amount of free gallic acid and ellagic acid. This study was performed to assess the antifungal effects of the extracts of Q. infectoria Galls, against Candida albicans with cup-plate agar diffusion method. In the present study the extract the plant was tested for their bioactivity against C. albicans. Extract of Q Infectoria Galls showed potential activity against the tested fungal isolate. According to the results of this study, the effect of Clotrimazole (positive control) was more than plant extracts effects, while the effect of antifungal drug Nystatin used in this study (Table 5) with the extract of Q. Infectoria Galls showed that Nystatin was effective in the treatment of candida infection with inhibition zone 28 mm at concentration 50 μg/ml, low activity at concentration 25 μg/ml with inhibition zone 14 mm and in active at concentration 12.5 μg/ml this means that Q. Infectoria Galls with more anticandidal potency than Nystatin chemotherapeutic antifungal agent used in this study. This study thus provides a useful database of the therapeutic bioactivity of Quercus Infectoria Galls against C. albicans, Thus effort must be making for isolation, standardization and clinical evaluation of such phytochemicals in order to obtain lead compounds for further new drug discovery.
Authors and Affiliations
Salah Eldin Omar Hussein
Keywords
Related Articles
- EP ID EP635366
- DOI -
- Views 172
- Downloads 0
COMPARISON OF CLINICAL RESPONSE BETWEEN SIX AND EIGHT CYCLES OF CHOP CHEMOTHERAPY IN NON HODGKIN LYMPHOMA
Background: Non Hodgkin lymphoma is one of the ten most common cancers in the developed world, it is one of the commonest malignancies in Sudan. There are a lot of treatment modalities used. This study is conducted to co...
AQUEOUS EXTRACT OF BEETROOT AGAINST METRONIDAZOLE TOXIC INFLUENCES ON GLUTATHIONE PEROXIDASE ACTIVITY, SPERMATOGENESIS AND HEMATOLOGICAL INDICES: IN VIVO STUDY
This study aimed to evaluate the possible antitoxic effect of beetroots extract against the toxic influences of metronidazole (MTZ) on Glutathione peroxidase activity, spermatogenesis and some of hematological indices in...
TEST VIABILITY MICROENCAPSULATION LACTOBACILLUS ACIDOPHILUS USING ALGINATE-CHITOSAN POLYMER IN SIMULATED GASTRIC FLUID
Objective: Lactobacillus acidophilus is one of the strains of lactic acid bacteria that has been widely used as a probiotic. The ability of Lactobacillus acidophilus to grow in the digestive system can suppress the growt...
RISK FACTORS FOR LATENT TUBERCULOSIS INFECTION IN CLOSE CONTACTS OF ACTIVE TUBERCULOSIS PATIENTS IN ALEPPO CITY
The diagnosis and treatment of latent tuberculosis infection (LTBI) have become mandatory toreduce the burden of tuberculosis worldwide. Close contacts of active TB patients are at high risk of both active and LTBI. The...
REVIEW ON PRONIOSOMES AS A NOVEL CARRIER FOR NOVEL DRUG DELIVERY SYSTEM
Proniosomes are liquid crystalline compact niosome hybrids which upon hydration form niosomes. It is drug with larger physical and chemical stability and potentially scalable for commercial viability. Proniosomes overcom...