Antihyperlipidemic Effect of Microbially Converted Eicosapentaenoic Acid from Rice Bran Oil in Rats
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2016, Vol 3, Issue 1
Abstract
Objective: Eicosapentaenoic acid (EPA) from fish oil is known to have favourable effects on cardiovascular system by lowering the elevated lipid levels. With the intention of producing an alternative vegetarian source to fish EPA, we have microbially synthesized EPA (mEPA) from α- linolenic acid (ALA) isolated from rice bran oil which was spectroscopically analysed. The objective of the present study was to evaluate the effect of mEPA on lipid profile in experimentally induced hyperlipidemic rats. Methods: Animals were divided into 12 groups of six animals each; control being treated with vehicle, 6 groups received normal diet while 6 groups received high fat diet. Both treatment groups received standard drug Atorvastatin (10 mg/ kg in saline, p.o.); three different doses of EPA (5, 10 and 50 mg/kg) and fish oil (1 g/ kg) for 28 days and were compared with sham hyperlipidemic rats. The hyperlipidemia was induced by high fat diet and lipid profile was estimated. Results: The elevated levels of LDL, VLDL and triglycerides in high fat diet induced animals were found to be decreased in the treatment groups whereas the decreased levels of HDL in hyperlipidemic group were significantly increased in the mEPA treated groups. The atherogenic index was improved with mEPA treatment. Conclusion: mEPA has shown promising antihyperlipidemic effect and can fulfil the need of alternative vegetarian source of EPA than fish oil to be used in the hypertensive hyperlipidemic conditions.
Authors and Affiliations
Shilpa A. Deshpande, Nandkishor J. Duragkar
Keywords
Related Articles
- EP ID EP240575
- DOI -
- Views 158
- Downloads 0
A cross sectional study on the practise of self-medication among 2nd year medical and dental students
Introduction: Most of the common health ailments are treated by general population themselves without medical supervision, which is termed as self-medication. There are potential risks of self-medications like adverse dr...
Pattern of Antibiotic prescription in Urinary tract Infection
Urinary tract infection (UTI) is a very commonly noted entity in clinical practice. UTI is defined as the presence of bacteria in urine along with symptoms of infection. Antimicrobials are used commonly for urinary tract...
Knowledge and attitude of MBBS undergraduate students for use of generic medicines at a tertiary care hospital
Introduction The cost incurred on medicine is one of the major concerning components of health expenditure Prescription of generic drugs can reduce the costs without reducing the quality of treatment Hence this study is...
Mechanisms, Methods of Detection and Causality Assessment of Adverse Drug Reactions
Adverse Drug Reactions are very common cause of hospital morbidity
Anti arthritic potentials of Piper betle- A preclinical study
The objective of the recent work was to evaluate the antiarthritic activity of Piper betle leaves against CFA induced arthritis in rats Antiarthritic activity of hydroalcoholic 14 extract of Piper betle leaves was invest...