Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study

Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 7

Abstract

Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension (HTN-OS group) that received additional induction of L-Nitro Arginine Methyl Esther (L-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide (NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson's Correlation. Results: The study showed a significant antihypertensive effect of the extract as compared with control group (P < 0.05) in both hypertensive models. Extract in the dose of 5 mg/kg showed the best blood pressure lowering effect. However, the correlation analysis did not show an association between NO increase and blood pressure lowering effect (P > 0.05). Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect.

Authors and Affiliations

Yori Yuliandra, A. Armenia, Helmi Arifin

Keywords

Related Articles

The road towards sustainable control of schistosomiasis in the Democratic Republic of Congo: Pre-assessment of staff performance and material resources in endemic regions

Objective: To improve knowledge and practice of health staff as well as the availability of material resources for diagnosis and management of schistosomiasis in two endemic provinces of DRC (Kinshasa and Bas-Congo). Met...

The healing effects of herbal preparations from Sambucus ebulus and Urtica dioica in full-thickness wound models

Objective: To investigate the healing effects of two herbal preparations. Methods: For this purpose, 106 wistar rats were divided into 9 groups including a control, eucerine, phenytoin, Urtica dioica (U. dioica) (2%), U....

A survey of biochemical and acute phase proteins changes in sheep experimentally infected with Anaplasma ovis

Objective:To determine the biochemical and acute phase proteins changes in sheep experimentally infected with Anaplasma ovis(A. ovis). Methods:One Iranian sheep naturally infected with A. ovis(parasitemia 0.02%) but wi...

Phytochemical analysis and antibacterial activities of Eleutherine bulbosa (Mill.) Urb. extract against Vibrio parahaemolyticus

Objective: To analyze compounds in Eleutherine bulbosa (E. bulbosa) (Mill.) Urb. extract and to determine its antibacterial capability against Vibrio parahaemolyticus (V. parahaemolyticus). Methods: E. bulbosa bulb extra...

Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G0/G1 and upregulating Bax

Objective: To determine the anti-proliferative activity of Abrus precatorius (A. precatorius) leaf extracts and their effect on cell death. Methods: A. precatorius leaves were extracted successively with hexane, ethyl ac...

Download PDF file
  • EP ID EP269194
  • DOI 10.1016/j.apjtb.2017.06.007
  • Views 79
  • Downloads 0

How To Cite

Yori Yuliandra, A. Armenia, Helmi Arifin (2017). Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study. Asian Pacific Journal of Tropical Biomedicine, 7(7), 614-618. https://www.europub.co.uk/articles/-A-269194