Antihypertensive and antioxidant activity of Cassytha filiformis L.: A correlative study
Journal Title: Asian Pacific Journal of Tropical Biomedicine - Year 2017, Vol 7, Issue 7
Abstract
Objective: To study the blood pressure lowering effect of Cassytha filiformis extract in animal models of hypertension and its correlation with the antioxidant activity. Methods: Male Sprague–Dawley rats were divided into two groups: endocrine hypertension (HTN group) that received a combination of prednisone and salt for two weeks and oxidative stress-associated hypertension (HTN-OS group) that received additional induction of L-Nitro Arginine Methyl Esther (L-NAME) for two days. Each group was subdivided into 4 and treated intravenously with the extract 5; 10; and 20 mg/kg, and vehicle control. The systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded. The blood was taken before and at the end of recording for the measurement of serum concentration of nitric oxide (NO). The changes of blood pressure were analyzed by two-way ANOVA while its correlation with NO concentration was analyzed by Pearson's Correlation. Results: The study showed a significant antihypertensive effect of the extract as compared with control group (P < 0.05) in both hypertensive models. Extract in the dose of 5 mg/kg showed the best blood pressure lowering effect. However, the correlation analysis did not show an association between NO increase and blood pressure lowering effect (P > 0.05). Conclusions: The study concludes that C. filiformis extract in the dose of 5 mg/kg exhibits the best blood pressure lowering effect in both animal models. Antihypertensive activity of the extract is not correlated with its antioxidant effect.
Authors and Affiliations
Yori Yuliandra, A. Armenia, Helmi Arifin
Keywords
Related Articles
- EP ID EP269194
- DOI 10.1016/j.apjtb.2017.06.007
- Views 77
- Downloads 0
Antioxidant potential of phenolic extracts of Mimusops elengi
Objective To evaluate the antioxidant potential of the phenolic extracts of Mimusops elengi (M. elengi) L. (Sapotaceae). Methods The extract of stem bark and seeds of M. elengi were prepared in methanol and acetone:wa...
Nationwide seroprevalence, spatial distribution and risk factors of Leishmania in Jordan
Objective: To explore the seroprevalence, spatial distribution and risk factors for Leishmania seropositivity in Jordan. Methods: Blood samples from 872 apparently healthy participants were randomly selected from 11 gove...
Cytotoxic, apoptotic and cell migration inhibitory effects of atranorin on SPC212 mesothelioma cells
Objective: To investigate the effects of atranorin, a lichen secondary metabolite, on SPC212 malignant mesothelioma cells in vitro. Methods: SPC212 malignant mesothelioma cell line was used. 3-(4,5-dimethylthiazol-2-yl)-...
Toxicity of cadmium and lead on tropical midge larvae, Chironomus kiiensis Tokunaga and Chironomus javanus Kieffer (Diptera: Chironomidae)
Objective To investigate the acute toxicity of cadmium and lead on larvae of two tropical Chironomid species, Chironomus kiiensis (C. kiiensis) Tokunaga and Chironomus javanus (C. javanus) Kieffer. Methods Different l...
A child with Erysipelothrix arthritis–beware of the little known
Erysipelothrix rhusiopathiae is an established animal pathogen while the zoonotic infections in humans are rarely reported. Infections occur after exposure to animals or animal products that are mostly occupational in ad...