Antimicrobial Activities of Some Pyrazoline and Hydrazone Derivatives
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2020, Vol 17, Issue 5
Abstract
Objectives: Resistance to antibiotics is recognized as one of the biggest threats to human health worldwide. Frequent and unnecessary use of antibiotics has caused infectious agents to adapt to antibiotics and thus drugs have become less effective. The resistance to many antibiotics necessitates the discovery of new antibiotics. In this study, two new and 23 previously reported 2-pyrazoline derivatives and one hydrazone derivative were evaluated for their in vitro antibacterial and antifungal activities. Materials and Methods: For the determination of the minimum inhibitory concentration (MIC) values of compounds, microbroth dilution was used. Results: The antimicrobial activities of the compounds were found in a wide range with MIC values of 32-512 μg/mL. Conclusion: The synthesized compounds showed moderate antimicrobial activity compared with the standards. They can be used as lead molecules for the synthesis of more effective compounds.
Authors and Affiliations
Begüm EVRANOS AKSÖZ, Suna Sibel GÜRPINAR, Müjde ERYILMAZ
Keywords
Related Articles
- EP ID EP689991
- DOI 10.4274/tjps.galenos.2019.42650
- Views 187
- Downloads 0
Antibacterial, Antifungal, and Antioxidant Activity of Cleome coluteoides: An In Vitro Comparative Study Between Leaves, Stems, and Flowers
Objectives: Cleome coluteoides, which belongs to the Capparidaceae family, and has been used in folk medicine for a long time. Our research aims to measure the antioxidant, antibacterial, and antifungal activities of C....
Evaluation of the Methylation and Acetylation Profiles of Dinitroaniline Herbicides and Resveratrol on the V79 Cell Line
Objectives: Herbicides are among the most widely used pesticide compounds for plant growth control worldwide. Risk assessment of the dinitroaniline-derived herbicides pendimethalin and trifluralin is important for foodbo...
A Synbiotic Mixture Augmented the Efficacy of Doxepin, Venlafaxine, and Fluvoxamine in a Mouse Model of Depression
Objectives: Currently available antidepressant drugs have notable downsides; in addition to their side effects and slow onset of action their moderate efficacy in some individuals may influence compliance. Previous liter...
Effects of Polyvinylpyrrolidone and Ethyl Cellulose in Polyurethane Electrospun Nanofibers on Morphology and Drug Release Characteristics
Objectives: Polyurethanes (PUs) are a popular choice for composing nanofibers due to their spinnability, biocompatibility, high chemical stability, and good mechanical and elasticity properties. The desired release behav...
Anti-inflammatory and Analgesic Effects of Limnophila repens (Benth.)
Objectives: The analgesic and anti-inflammatory effects of methanolic extract of Limnophila repens (MELR) were assessed at 200 and 400 mg/kg. Materials and Methods: In carrageenan-mediated paw edema, the anti-inflammato...