Antioxidant and anticancer activities of an Aporphine alkaloid isolated from Alphonsea sclerocarpa
Journal Title: The Journal of Phytopharmacology - Year 2018, Vol 7, Issue 1
Abstract
Herein, we report on the anticancer and antioxidant activity of an Aporphine alkaloid isolated from medicinal plant Alphonsea sclerocarpa. Conventional column chromatography and preparative HPLC methods were used to isolate and purify the alkaloid. Based on NMR, FTIR and MS/MS spectroscopic techniques the compound was identified as Crebanine. This is the first report on the presence of Crebanine from the leaves of Alphonsea sclerocarpa. Antioxidant activity was evaluated using DPPH and FRAP assay. The antioxidant activity was dose-dependent and activity increased with the increase in the concentration. The cytotoxicity assay was carried out using MTT assay. The results showed remarkable cytotoxic activity against K562 (CML-chronic myeloid Leukaemia blood cancer) cells with a % inhibition of 37.545 at 500µm concentration after an incubation of 24h.
Authors and Affiliations
Suman Joshi DSD, Chander Amgoth, Surya Narayana S, Padmavathi CH, Madhavi J, Krishna Satya A
Keywords
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