Antioxidant and in vivo Wound Healing Activities of Clausena anisata
Journal Title: European Journal of Medicinal Plants - Year 2015, Vol 10, Issue 2
Abstract
Leaves of Clausena anisata are used in many parts of West Africa including Ghana for management of wounds and other skin infections. The study was to evaluate the in vivo wound healing and antioxidant properties of ethanol leaf extract of C. anisata. The wound healing activity of ethanol leaf extract of the C. anisata was investigated using excision wound model. The antioxidant activity was determined using 2, 2-diphenyl-1 picrylhydrazyl (DPPH) free radical scavenging method. For wound healing activity, concentrations of 7 and 10% w/w aqueous cream of the extract were used. The progression of wound healing was determined by the periodic assessment of the contraction of excision wounds and histological studies. The leaf extract cream (7% w/w) was found to significantly increase the rate of wound contraction (p<0.001) at days 13 to 19 compared to the untreated. The n-propyl gallate used as the reference antioxidant agent had IC50 of 4.19 μg/mL and that of the ethanol extract was 32.9 μg/mL. These findings may justify the medicinal uses of C. anisata for the management of wounds.
Authors and Affiliations
Nicholas Agyepong, Christian Agyare, Paul Poku Sampene Ossei, Yaw Duah Boakye
Keywords
Related Articles
- EP ID EP350079
- DOI 10.9734/EJMP/2015/19792
- Views 117
- Downloads 0
Loranthus micranthus Leaves Extract Attenuates Risk Factors of Cardiovascular Disease in Fructose Fed Rats
Aims: Today there are concerns about possible adverse effects of dietary sugars. This study was set up to compare the metabolic dysfunction induced by dietary fructose in male rats with that of the female, investigate t...
Effects of Chemical and Biological Fertilizers on Morpho-Physiological Traits of Marigold (Calendula officinalis L.)
Aims: Fertilizer management is an important factor for a successful growth of officinal plants and the identity of suitable fertilizers in plants could have the desirable effects on quantitative and qualitative indices....
Ovicidal and Larvicidal Effects of Ricinus communis L. (Euphorbiaceae) Extracts on Phlebotomus duboscqi
Aims: To evaluate the Ovicidal and larvicidal effects of Ricinus communis (Euphorbiaceae) extracts on Phlebotomus duboscqi. Study Design: A comparative experimental design using extracts obtained from the leaf and bark...
Proximate Compositions and Antibacterial Activity of Citrus sinensis (Sweet Orange) Peel and Seed Extracts
Aim: This study evaluated the proximate composition and antibacterial activity of the Citrus sinensis (sweet orange) fruit waste (peels and seeds). Study Design: The peels and seeds from Linnaeus Osbeck variety of Citrus...
Phytochemicals of Markhamia Species (Bignoniaceae) and Their Therapeutic Value: A Review
Aims: To present a compilation of data regarding the phytochemical content and pharmacological activities pertaining to genus Markhamia as one of 120 genera belonging to family Bignoniaceae. Study Design: Literature wa...