ANTIOXIDANT EFFECTS OF LOVASTATIN ON COPPER-MEDIATED IN-VITRO OXIDATIVE MODIFICATION OF LDL IN INFLAMMATION INDUCED HYPERLIPIDEMIA IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Cardiovascular diseases (CVD) are the main cause of disability and premature dead worldwide. Epidemiological studies have suggested a link between atherosclerosis and inflammation. Atherosclerosis is a multifaceted diseases process with several different well defined risks factors, such as hypercholesterolemia, hypertension and diabetes. The present study was carried out to investigate the efficacy of antioxidant agent lovastatin. The study comprises the antioxidant status of Lovastatin by analyzing all the parameters in plasma, TL, TC, TG, VLDL-C, LDL-C, non-HDL-C, MDA and in-vitro oxidizability of LDL in absence or presence of Lovastatin. All the plasma lipids parameters, TL, TC, TG, VLDL-C, LDL-C, non-HDL-C and MDA levels were significantly increased in inflammation induced hyperlipidemic (IIH-C) rats. After 4-weeks administration of Lovastatin (1mg/ml) to IIH-C rats were useful in the prevention and treatment of inflammation induced hyperlipidemia, CVD and atherosclerosis. Lovastatin significantly reduced the overall oxidative burden and effectively ameliorated the above altered parameters.
Authors and Affiliations
Amir Khan, Jawed Shozab , Mahesha Nand, Lakhvinder Singh, Rishab Jain , Munish Thakur
Keywords
Related Articles
- EP ID EP119627
- DOI -
- Views 132
- Downloads 0
DIVERSE PHARMACOLOGICAL ACTIVITIES OF 3-SUBSTITUTED COUMARINS: A REVIEW
Coumarins belong to the family of lactones having benzopyrone system that can be isolated from plants as well as total synthesis can be carried out in the laboratory. To date, many chemical reactions have been establishe...
LEECH ON EXTERNAL THROMBOSED HEMORRHOIDS
Arshas or hemorrhoids included under the category of Mahagadas as it significantly disturbs the normal proceedings or activities of the body like an enemy. It is a guda gata mamsa vikara occurs in three valis of the ano...
EVALUATION OF ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITIES OF FLOATING MICROSPHERES OF HERBAL DRUG
The aim of the present studies was to prepare and evaluate floating microspheres of curcumin for anti-inflammatory and anti-arthritic effect. Floating microsphere were prepared using hydroxyl propyl methylcellulose (HPMC...
EFFECT OF ETHYL ACETATE EXTRACT OF BLACK TEA ON CARDIOVASCULAR COMPLICATIONS ASSOCIATED WITH STREPTOZOTOCIN DIABETIC RATS
Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and microvascular complications. These complications contribute to the morbidity and mortality associated with the disease. There...
EVALUATION OF ANTIMICROBIAL ACTIVITY OF AERVA LANATA ALONG WITH PRELIMINARY PHYTOCHEMICAL SCREENING
The aim of the present study was to investigate the antibacterial properties and phytochemical evaluation of of Aerva lanata. The organic solvent ( Ethanol, Methanol, Hexane) and water extracts from the whole plant of A...