Antiphospholipid autoantibodies testing in women with unexplained infertility and recurrent first trimester abortion
Journal Title: Obs Gyne Review: Journal of Obstetric and Gynecology - Year 2015, Vol 1, Issue 1
Abstract
Objective: To assess the occurrence of antiphospholipid auto-antibodies (aPLA) in women suffering from unexplained infertility or recurrent first trimester abortion to evaluate their pathogenic role in these disorders. Setting: King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia. Patients and Methods: Between June 2013 and December 2014, a prospective study was carried out on 20 women with unexplained fertility (group A), 20 women with recurrent first trimester abortion (group B), compared to 20 healthy women as control (group C). IgA, IgM, and IgG against phospholipids were detected in the sera of all cases. Results: It was found that IgA, IgM and IgG levels were significantly higher in group A, B when compared to group C. Venereal Diseases Research Laboratory (VDRL) test was positive in 2 (10%) cases in group A and 3 (15%) cases in group B but it was negative in group C. Lupus anticoagulant (LA), tested by the activated partial thromboplastin time (APTT), was prolonged in 4 (20%) group A and 3 (15%) cases in group B. Conclusion: From the results of this study it can be concluded that reproductive performance may be affected by the abnormal presence of antiphospholipid auto-antibodies.
Authors and Affiliations
Nisreen Khalid Aref AL Bezrah
Keywords
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- EP ID EP331848
- DOI 10.17511/jobg.2015.i1.03.
- Views 197
- Downloads 0
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