ANTITESTICULAR ACTIVITY OF HYDRO-METHANOL EXTRACT OF CUMINUM CYMINUM IN ADULT RAT: A DOSE DEPENDENT STUDY
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 3
Abstract
Objective: The present study was to evaluate the dose-dependent effects of Cuminum cyminum (C. cyminum) on testicular gametogenic and androgenic activities in adult rat.Methods: The hydro-methanolic extract was administered orally at the dose of 30mg, 60mg and 120mg/100g body weight of rats for 28 days. The effects of the treatment on reproductive organs and testicular steroidogenesis were investigated. Toxicity studies were also carried out.Results: Treatment with this extract resulted in significant reduction in the weights of relative sex organs. A significant decrease in the androgenic key enzyme activities, plasma testosterone level, seminal fructose level, along with an increase in the level of testicular cholesterol in respect to the control was observed. Values of spermatological parameters and the activities of anti oxidative enzymes were reduced significantly, whereas the end products of lipid peroxidation in testis, epididymis and sperm pellet were significantly increased in treated groups. After the extract treatment, the count of different generations of germ cells at the stage VII of the spermatogenic cycle and Seminiferous Tubular Diameter (STD) were decreased significantly. Activities of Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) in liver and kidney tissue were not altered significantly from the control. The said effects were exhibited in a dose dependent fashion, but all these effects were more significant at the dose of 60 mg/100g body weight.Conclusion: It may be concluded that 60 mg dose of the hydro-methanol extract showed a promising contraceptive activity by the diminution in testicular gametogenesis and androgenesis without producing any toxicity.Â
Authors and Affiliations
Bhabani Prasad Pakhira, Kishalay Jana, Abhinandan Ghosh, Debidas Ghosh
Keywords
Related Articles
- EP ID EP578976
- DOI -
- Views 91
- Downloads 0
FORMULATION AND EVALUATION OF LEVODOPA EFFERVESCENT FLOATING TABLETS
Objective: Levodopa is an immediate precursor of dopamine used in treatment of Parkinsonism disorders. The Levodopa effervescent floating tablets were prepared by direct compression technique, using different low density...
COMPARATIVE SEQUENCE ANALYSIS OF TLR2 TLR4 AND TLR9 GENES AMONG SELECTED VERTEBRATES-A META-ANALYSIS
Objective: Toll-like receptors are the pattern recognition receptors that recognize a diverse set of conserved pathogens. The receptors are also constantly under selection pressure because of the host antigen modificatio...
THE ROLE OF HONEY WITH ROYAL JELLY IN PROTECTING THE GRAAFIAN FOLLICLES FROM THE TOXICITY OF THE ADRIAMYCIN DRUG
Objective: This study aims to investigate the ability of certain mixture of honey with royal jelly (H+R) to prevent the toxic side effects, caused by the Adriamycin drug. One of the most important side effects of this dr...
DOCKING STUDY OF ALLICIN WITH SULFONYLUREA RECEPTOR 1, COMPLEX 1 AND PPARγ RECEPTOR ON INSULIN RESISTANCE
Objective: Allicin is a potential type 2 antidiabetic. Sulfonylurea receptor 1 (SUR1), nikotinamida adina dinukleotida dehydrogenase (Complex 1) and peroxisome proliferator-activated receptors gamma (PPARγ) are known as...
EFFECT OF SOLVENT EXTRACTION SYSTEM ON THE ANTIOXIDANT ACTIVITIES OF ALGAE
Objective: The present study aimed to determine the antioxidant activities of five algae including Oedogonium globossum, Pithophora oedogonia, Rhizoclonium hieroglyphicum, Scytonema ocellatum and Spirogyra communis and t...