Anxiolytic Effect of Citrus paradisi var. Marsh seedless Using Different Models
Journal Title: International Neuropsychiatric Disease Journal - Year 2015, Vol 4, Issue 3
Abstract
Aims: The present study was designed to evaluate the anti-anxiety activity of various extracts of the leaves of Citrus paradisi var. Marsh seedless using light dark model and hole board methods in Swiss albino mice. Methodology: Swiss Albino mice were treated with different doses of the extracts (50,100,200 and 400 mg/kg p.o.) and Diazepam (2 mg/kg, p.o) was used as a positive control using Hole Board test and light dark model. Results: Results showed that methanol extract in doses of 100 mg/kg p.o. and 200 mg/kg p.o. possesses marked anti anxiety activity. This effect was comparable to the effect produced by standard drug, diazepam. Conclusion: Hence this plant may be developed as a potentially useful anxiolytic agent. Further studies are going on to find out the active constituent responsible for this activity.
Authors and Affiliations
Vikas Gupta, Parveen Bansal, Kamlesh Kohli, Pankaj Ghaiye
Keywords
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- EP ID EP241544
- DOI 10.9734/INDJ/2015/18699
- Views 131
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