APHRODISIAC AND FERTILITY ENHANCING ACTIONS OF ‘KUNU AYA’ (A BEVERAGE BLEND DEVELOPED FROM CYPERUS ESCULENTUS, PHOENIX DACTYLIFERA AND COCOS NUCIFERA) VIA TESTOSTERONE- BOOSTING, ANXIOLYSIS AND INHIBITION OF KEY ENZYMES ASSOCIATED WITH ERECTILE PROCESS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
Sexual dysfunctions occur at a point in an adult‟s lifetime. To address this problem a number of therapeutic strategies have been developed, some of which are inadequate and/or plagued with side effects. Consequently, alternative methods which include the use of herbs with aphrodisiac and fertility- enhancing properties have been advocated. The present study investigated the mechanism of aphrodisiac and fertility- enhancing activities of aqueous extracts of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera and ‘Kunu aya’ (the beverage blend). The study was divided into in vivo and in vitro phases. In the in vivo phase, aphrodisiac and fertility- enhancing activities of the extracts were assessed in rats using physical/ behavioral (observation of mounting/ mating frequencies), biochemical (determination of sperm count, testosterone and PSA levels) psychological/ mood (anxiolytic effect using EPM models) methods while in the in vitro phase, different concentrations of each extract were subjected to phosphodiesterase- 5 (PDE-5), Arginase, Acetylcholinesterase (AChE), Angiotensin Converting Enzyme (ACE) inhibition assays and their medium inhibitory concentrations (IC50) determined through non-linear regression analysis. Results showed that the beverage blend significantly increased mounting/ mating frequency, sperm count, testosterone level, decreased PSA level and reduced anxiety. The blend was also more potent in inhibiting the enzymes compared to the individual extracts. It was then concluded that the possible mechanisms of aphrodisiac and fertility- enhancing properties of the individual extracts and their beverage blend- „Kunu aya’ are via ability to increase testosterone level, increase sperm count, decrease anxiety and inhibition of key enzymes involved in erectile process.
Authors and Affiliations
Idakwoji Precious Adejoh
Keywords
Related Articles
- EP ID EP618612
- DOI -
- Views 160
- Downloads 0
PITUITARY DISORDERS IN PREGNANCY
Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to ph...
BREASTFEEDING AND IT’S RELATION TO THE WEIGHT OF CHILDREN FROM 3 TO 6 YEAR OLD IN AL-HASSA
Background: Obesity is defined as excessive accumulation of fatty tissue that can hinder the effective functioning of the human body. As a result, health problems may ensue, leading to a poor quality of life and decrease...
IMPROVEMENT OF GLUCOSE TOLERANCE WITH A POLYHERBAL FORMULATION OF BRASSICA RAPA SUBSP. RAPA ROOTS AND ZINGIBER OFFICINALE RHIZOMES
Background. Brassica rapa subsp. rapa (Brassicaceae family) and Zingiber officinale (Zingiberaceae family) are two plants cultivated in Bangladesh, respectively, for consumption as vegetable and as spice. A number of Bra...
PHYSICO-TECHNICAL PROPERTIES OF THE GRANULES AND TABLETS OF MICRONISED MORINGA OLEIFERA LEAF: THE EFFECT OF BINDERS
Background: An important challenge militating against the general acceptance of herbal medicines is the formulation of appropriate dosage form that meets conventional quality standards. Thus, the objectives of this study...
AUTOGENOUS BONE BLOCK GRAFTS
Reconstruction of alveolar ridge deficiencies requires bone augmentation before implantplacement. Osseous defects occur as a result of trauma, prolonged edentulism, congenitalanomalies, periodontal disease, and infection...