Application of adenovirus vector in cancer gene therapy and vaccination
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 1
Abstract
Adenovirus vector is one of the most widely used viral vectors for gene therapy. Compared with other viral vectors, adenovirus has various advantages such as high transduction effi ciency, broad tropism for diff erent tissues and epichromosomal persistence in the host cell, etc. Adenovirus vectors can be modifi ed as replication-deficient and replication-selective oncolytic virus vector. The strong immunogenicity of adenovirus vector makes it suitable to be applied in genetic vaccines and anti-cancer therapies. At present, many clinical trials have confirmed the safety and effectiveness of adenovirus vector in the above-mentioned therapeutic attempts.
Authors and Affiliations
Xie Qian, Gao Xiang, Wang Yi
Keywords
Related Articles
- EP ID EP767199
- DOI 10.12287/j.issn.2096-8965.20210112
- Views 13
- Downloads 0
Research progress and translational application of molecular markers of lung cancer
The translational medicine has improved the development of basic medicine such as molecular biology and has changed the medical model. The aim of translational medicine is to translate the basic research achievement of m...
Research progress and application of artificial intelligence technology in lung cancer diagnosis
The use of artificial intelligence in the medical field has become increasingly widespread, particularly in the diagnosis of lung cancer. Early and accurate diagnosis of lung cancer is crucial for effective treatment and...
Progress in diagnosis and treatment of androgenetic alopecia
Androgenetic alopecia (AGA) is a very common hair disease, which occurs in both males and females. The clinical manifestations of AGA mainly include miniaturization of hair, thinning of hair and upward movement of hairli...
Progresses in research and development of antibody-drug conjugate
Through referring to the literature and related databases, the research process of antibodyconjugated drugs was reviewed, and the key elements of ADC were summarized. Twelve ADCs have been approved worldwide, since the...
Application of deep learning network in clinical diagnosis of active pulmonary tuberculosis based on CD161
Objective To explore the diagnostic value of cell surface molecule CD161 by flow cytometry technology, and to establish deep learning networks that can distinguish sputum smear-negative pulmonary tuber‐ culosis, sputum s...