Application of three-dimensional culture in the study of glaucoma
Journal Title: Eye Science (Yanke Xuebao) - Year 2024, Vol 39, Issue 8
Abstract
Glaucoma is the world's first irreversible blinding eye disease, characterized by degenerative changes in retinal ganglion cells (RGCs), which have a significant impact on the global economy and health. The molecular and biological mechanisms of its pathological changes are still unclear. At present, glaucoma surgery and drug therapy are still limited to controlling the intraocular pressure in the normal range. Three-dimensional culture technology can enable cells to form a certain spatial structure in vitro, which is conducive to cell-cell and cell-environment interactions. Compared with traditional two-dimensional culture, three-dimensional culture technology is closer to the physiological environment of cells in vivo, which is of great significance for the study of pathophysiological changes of diseases and high-throughput drug screening. This review discusses the application of trabecular mesh and three-dimensional culture of retinal cells in the basic research of glaucoma, aiming to provide new ideas for further exploring the pathophysiological mechanism of glaucoma.
Authors and Affiliations
Yufan JIANG, Yutong CHE, Yangfan YANG
Keywords
Related Articles
- EP ID EP761473
- DOI 10.12419/24073102
- Views 21
- Downloads 0
Comparison of the efficacy of laser photocoagulation and anti-VEGF in the treatment of type 1 prethreshold retinopathy of prematurity
[Objective:] To observe the efficacy of laser photocoagulation (LP) and intravitreal ranibizumab (IVR) injection in the treatment of type 1 prethreshold retinopathy of prematurity (ROP) with lesions located in zone II. [...
Research progress on the structure and functional regulation of Schlemm’s canal and its application in glaucoma treatment
Schlemm's canal (SC), as the primary pathway for aqueous humor drainage, maintains intraocular pressure balance by regulating aqueous outflow. Abnormalities in its structure and function are closely associated with eleva...
Clinical innovation research model for fundus diseases: 6 elements, 3 ones
The "6 Elements, 3 Ones" constitutes a methodological framework for conducting innovative clinical research of ocular fundus diseases in foundational fundus imaging interpretation. This model emphasizes: 1) identifying a...
Analysis of influencing factors and General Well-Being Schedule evaluation in early-postoperative cataract patients during the COVID-19 epidemic
[Objective:] To evaluate the general well-being and its associated factors for the early-postoperative patients with different types of cataract during the epidemic of corona virus disease 2019 (COVID-19), and to provide...
Correlation of risk factors of diabetic retinopathy in Han population in Hunan
[Objective:] To analyze the demographic characteristics and biochemical indexes of type 2 diabetic patients in Han population in Hunan, and to find the high-risk factors of diabetic retinopathy. [Methods:] The data of de...