Application value of serum carbonic anhydrase Ⅲ as a new biomarker in the clinical diagnosis of Alzheimer disease

Journal Title: 中国临床医学(Chinese Journal of Clinical Medicine) - Year 2024, Vol 31, Issue 5

Abstract

ObjectiveTo explore the application value and related factors of serum carbonic anhydrase Ⅲ (CAⅢ) in the clinical diagnosis of mild to moderate Alzheimer disease (AD). MethodsA total of 106 elderly patients initially diagnosed with mild to moderate AD at Huashan Hospital, Fudan University from October 2020 to November 2022 were enrolled as the AD group, and 89 healthy elderly people during the same period were enrolled as the control group. The serum biochemical indicators including liver and kidney function, blood lipids, blood glucose, folic acid and homocysteine were detected in both groups. Cognitive function was assessed by Mini-mental State Examination (MMSE). Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) were used to assess psychological status. The activities of daily living (ADL) were assessed by modified Barthel Index (BI). Serum CAⅢ levels were measured by enzyme-linked immunosorbent assay (ELISA). Correlation analysis and multivariate linear regression analysis were used to identify factors influencing serum CAⅢ levels, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of serum CAⅢ levels in elderly patients with mild to moderate AD. ResultsThe MMSE score of the AD group was significantly lower than that of the control group (P<0.001), and the PHQ-9 and GAD-7 scores were significantly higher than those of the control group (P<0.001). The serum CAⅢ level in the AD group was significantly lower than that in the control group (P<0.000 1). In patients with AD, serum CAⅢ levels in patients with a disease course >3 years, accompanied by depression or anxiety, moderate AD, and serum creatinine≤111 μmol/L were significantly lower than those in patients with a disease course ≤3 years, normal emotions, mild AD, and serum creatinine >111 μmol/L (P<0.05). Correlation analysis and multivariate linear regression analysis showed that serum CAⅢ levels were negatively correlated with disease duration, PHQ-9 score, GAD-7 scores and severity degree, positively correlated with serum creatinine level (P<0.05). The PHQ-9 score, severity degree, and serum creatinine level were independent related factors for serum CAⅢ level in mild to moderate AD elderly patients (P<0.05). ROC curve result showed that the area under the curve (AUC) of serum CAⅢ in diagnosing mild to moderate AD in elderly patients was 0.946, with sensitivity and specificity of 88.79% and 96.74%, respectively. ConclusionsSerum CAⅢ levels in elderly patients with mild to moderate AD are higher than those in healthy individuals. Mild AD, without depressive mood, and elevated serum creatinine levels are related factors for elevated serum CAⅢ levels in elderly AD patients. Serum CAⅢ may serve as a novel biological marker for the diagnosis of mild to moderate AD in the elderly.

Authors and Affiliations

Jiaoqi REN, Jinxiu WANG, Jiantao WANG, Yanli ZHANG, Xuechun WANG, Jingchun GUO, Houguang ZHOU

Keywords

Related Articles

Predictive value of 3D quantitative shape features based on CT for disease-free survival of primary gastrointestinal stromal tumors

ObjectiveTo explore the predictive value of 3D quantitative shape features based on enhanced CT for disease-free survival (DFS) of primary gastric gastrointestinal stromal tumors (GIST) patients receiving curative resect...

Clinical status and challenges of respiratory virus rapid detection

Acute respiratory infections pose a significant burden to global health systems, with viral pathogens as the major contributors. Rapid and accurate pathogen diagnosis is of great significance for timely antiviral treatme...

Effect of sluggish cognitive tempo on the efficacy of atomoxetine in children with attention-deficit/hyperactivity disorder

ObjectiveTo explore the impact of sluggish cognitive tempo (SCT) on the efficacy of atomoxetine in the treatment of attention-deficit/hyperactivity disorder (ADHD). MethodsA prospective study was conducted. Pediatric pat...

Research progress for the clinical application of radionuclide labeling fibroblast activation protein inhibitor in the diagnosis and treatment of liver cancer

Liver cancer has high morbidity and mortality worldwide. Traditional morphological imaging can offer crucial anatomical information for the diagnosis and treatment of liver cancer, and when combined with the functional d...

The relationship between dietary fiber intake and hypertension: an analysis based on the NHANES data from 2015 — 2016 in the United States

Objective To explore the relationship between dietary fiber intake and hypertension in different populations. Methods Dietary fiber intake was calculated using the data from 2015—2016 National Health and Nutrition...

Download PDF file
  • EP ID EP749362
  • DOI -
  • Views 52
  • Downloads 0

How To Cite

Jiaoqi REN, Jinxiu WANG, Jiantao WANG, Yanli ZHANG, Xuechun WANG, Jingchun GUO, Houguang ZHOU (2024). Application value of serum carbonic anhydrase Ⅲ as a new biomarker in the clinical diagnosis of Alzheimer disease. 中国临床医学(Chinese Journal of Clinical Medicine), 31(5), -. https://www.europub.co.uk/articles/-A-749362