Arginase: An Emerging Key Player in Periodontal Disease and Diabetes Mellitus.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
Introduction: Arginase is a semi-essential amino acid, an enzyme found in saliva which is involved in inflammation.Arginase is found mainly in the human liver, also found in salivary glands. Saliva is an important biological material containing local and systemic derived markers. Analysis of arginase may be used as a diagnostic aid to evaluate the periodontal status and to clearly understand the pathogenic process of periodontal disease. Aims And Objectives: To evaluate arginase levels in healthy, gingivitis, chronic periodontitis, and chronic periodontitis subjects with diabetes mellitus and to compare it with clinical parameters. Methodology: Total of 100 patients, divided into 25 healthy subjects, 25 gingivitis subjects, 25 chronic periodontitis subjects(CP), 25 chronic periodontitis (CP) subjects with Type2 Diabetes mellitus (Ty2DM). Duly signed informed consent was obtained from all the subjects and saliva samples were collected. Arginase activity was measured by UV spectrophotometry at 515nm. Result: Arginase level in CP subjects and CP subjects with Ty2DM are significantly higher than subjects with healthy and gingivitis. Conclusion: Early evaluation of periodontal status is essential to prevent the progression of the disease. Salivary arginase levels can be used as a reliable marker in periodontal disease also can be regarded as a novel marker for the vascular complications of diabetes.
Authors and Affiliations
Dr. Nagaraj B. Kalburgi
Keywords
Related Articles
- EP ID EP577237
- DOI -
- Views 81
- Downloads 0
Rehabilitation of completely edentulous patient with implant supported fixed prosthesis- A case report.
Full arch implant supported fixed prosthesis is a viable treatment option for edentulous patients seeking esthetics, function and comfort, providing the sense of security, naturalness, and immediate...
A Survey for Evaluating the Awarness, Knowledge and Perception of Various Treatment Modalities forReplacement of Missing Teeth.
Aim: To assess the general awareness of the various treatment modalities for replacement of missing teeth among individuals and their choice of treatment. Methodology: A survey was conducted among...
Radiographic Profile of Symptomatic Impacted Mandibular Third Molars in the Arab Israeli Population.
Introduction: Impaction may be defined as the failure of complete eruption into a normal functional position of one tooth within normal time due to lack of space in the dental arch, caused by obstruction by another tooth...
Anti-Apoptotic Gene: Survivin.
In developing countries where most people live in rural areas, oral cancer tends to be a challenge in diagnosis and management, as most of the cases present at a later stage. Carcinogenesis is a multifactorial process wh...
Complications of Dental Implants Associated With Augmentation Procedure and Its Management: A Review.
Treatment with dental implants has evolved from earlier much old procedures to a mainstream clinical activity however its potential benefits and high success rates have led to procedures sometimes being incorrectly used...