Assessment of antioxidant enzyme status and lipid peroxidation in different KL grade knee osteoarthritis patients
Journal Title: Santosh University Journal of Health Sciences - Year 2018, Vol 4, Issue 2
Abstract
Introduction Although limited information is available about the pathophysiology of knee osteoarthritis OA disease in relation with oxidative stress there is a paucity of satisfactory explanation regarding the alteration in the level of antioxidant enzymes and lipid peroxidation with severity of knee OAAim To estimate the levels of antioxidant enzymes and malondialdehyde MDA in the knee OA patients of different KL grade and to determine the variation in their levels with severity of diseaseMaterials and Methods Antioxidant enzyme status superoxide dismutase and ceruloplasmin and malondialdehyde levels were measured in 150 knee OA patients 3565 years by using standard methods On the basis of KL grading scale Knee OA patients were categorized into three groups n50 in each group and statistically compared it with that of 50 healthy controls by using students ttestResults Erythrocyte superoxide dismutase activity was significantly low in Group II P Conclusion Study findings indicate that alteration in antioxidant enzyme status and increased production of MDA are excellent marker of oxidative stress in different grades of knee OA patients Thus the diet rich in antioxidant or antioxidant supplementation could be beneficial in delaying the progressive destruction of articular cartilage process and serve as a preventive strategy in field of knee OA managementKeywords Superoxide dismutase ceruloplasmin free radicals Malondialdehyde Oxidative stress
Authors and Affiliations
Jyoti Batra, Rahul Saxena, Gladys Rai, Saurabh Srivastava, Rajni Ranjan
Keywords
Related Articles
- EP ID EP488986
- DOI 10.18231/2455-1732.2018.0022
- Views 113
- Downloads 0
Forgotten Forensics: Enamel Choumps-Case Report and Review
From the various forms of body decorations and mutilation which are seen in different societies, mutilation and adornment of the teeth and oral soft tissues comprise a group of practices of obvious forensic significance...
Anecdotes from History
Doctors are the part of a great science that has direct influence on the wellbeing of human life. With the continuous evolvement of this science, came many great inventions and discoveries which mitigated human suffering...
Detection of bacterial and intestinal parasitic infections among children under 5 years of age with acute gastroenteritis in a tertiary care hospital in NCR region
Introduction Acute gastroenteritis AGE accounts for millions of deaths each year in children mostly in developing countries Wide range of pathogens including parasites bacteria and viruses are responsible for AGE The aim...
Current recommendation for adult immunization: An update
Vaccines received as children will not protect adult for the rest of their lives. New vaccines such as the chickenpox vaccination were not available when many adults were children. And vaccinations for certain diseases m...
Physical physiological and biochemical changes during pregnancy
Pregnancy is associated various physiological changes in order to ensure care support and protection of the developing embryo and also prepare mother for labour and delivery These changes influence all physical physiolog...