Assessment of Biofilm Production in Carbapenem Resistant Acinetobacter Species Isolated from Different Clinical Specimens
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 10
Abstract
Introduction: Microbial biofilms are important virulence factors contributing not only to the severity of the disease process but also to the antibiotic resistance. Acinetobacter species, particularly Acinetobacter baumannii is an important pathogen causing nosocomial outbreaks of infection in healthcare settings. Herein, we evaluated the biofilm forming ability of Carbapenem resistant Acinetobacter isolated from various clinical specimens. Methods: A total of 109 phenotypically identified Acinetobacter isolates from different clinical specimens were studied, in which, Carbapenem resistance was determined as per the CLSI guidelines. Those isolates were then quantitatively assessed for their biofilm forming ability using the Microtitre Plate Assay. Results: Of the 109 Acinetobacter isolates studied, 64.2% were Carbapenem resistant. Among them, 77.1% were biofilm formers. There was significant association seen between Carbapenem resistance and biofilm formation (p = 0.024). Odds ratio calculated was 2.6. Conclusion: Our study showed that among the Carbapenem resistant strains of Acinetobacter, a significant number were biofilm producers. Further genetic analysis may provide a better understanding of the virulence, multidrug resistance and survival of the bacteria in the hospital environment
Authors and Affiliations
Amrita Pattanaik
Keywords
Related Articles
- EP ID EP529411
- DOI -
- Views 85
- Downloads 0
Evaluation of Bronchodilator Activity of Siddha Herbo Mineral Drug “Vasanthakusumakara Mathirai” by Exposing Guinea Pig in Histamine Aerosol
Asthma is an inflammatory disease of the small airways characterized by episodic, reversible bronchial obstruction, polyphonic wheeze, dyspnoea, and cough which may be relieved spontaneously or as a result of therapy. As...
Surveillance Eclampsia in a tertiary care teaching hospital: Our experience
Objective: To watch the maternal and Perinatal result in eclampsia. Material and Methods: Data was gathered from eclamptic ladies admitted to the crisis ward of Obstetrics and gynecology of IMS and SUM doctor's facility,...
Bilateral Accessory Renal Arteries: A Case Report
Anomalous blood vesseles are always interesting from a purely scientific point of view, especially since they so often shed light on obscure problems of phylogeny and ontogeny. The evolutionary history of kidney and rena...
Prevention of Preterm Labour in High Risk Woman by Vaginally Administered Natural Micronized Progesterone in Tertiary Care Hospital at Muzaffarpur, Bihar
Objective: A Prospective study to evaluate the effect of Prophylactic administration of natural micronized progesterone vaginally, on the occurrence of spontaneous Preterm birth in high risk woman. Materials and Methods:...
Demography, Clinico-Pathological Features and Outcome of Extrapulmonay Tuberculosis: 2 Years Prospective Study
Tuberculosis (TB) is an infectious disease that primarily affects lungs followed by other organs. Extrapulmonary TB can present with non-specific symptoms such as unintentional weight loss (more than 1.5 kg in a month),...