Assessment of Glutathione peroxidase and its correlation with the components of Metabolic Syndrome
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 5
Abstract
Abstract: Metabolic syndrome (MS) is a cluster of cardiometabolic risk factors such as obesity, hyperglycemia, dyslipidemia, and hypertension and insulin resistance. However, the role of oxidative stress in developing components of MS needs further investigations. The objective of present study was to study the levels of antioxidant enzyme Glutathione peroxidase (GSHPx) and correlate them with components of MS. 300 participants were enrolled, which were divided into MS positive (n=150) and MS negative (n=150) groups as per NCEP ATP III criteria. Components of MS were assessed using standard methods and data from patients and controls were compared by using Student’s t-test. Correlation of GSHPx with the components of MS was carried out using Pearson correlation coefficient.Erythrocyte GSHPx activity was decreased significantly in patient group subjects. In addition, GSHPx activity was negatively correlated with the components of MS. Oxidative stress is significantly associated with MS and its components. Furthermore, components of MS should be monitored regularly with advancing of age in order to overcome the burden of cardiovascular disease risk. Keywords:Hyperglycemia, hypertriglyceridemia, dyslipidemia, abdominal obesity, free radical
Authors and Affiliations
Rajeev Goyal, Manoj Kumar Nandkeoliar, Vartika Saxena, Pramod Payal, Rahul Saxena
Keywords
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