Assessment of IL-10 Polymorphism and TGF beta 1 Polymorphism in Egyptian Patients with Chronic Liver Disease
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 8
Abstract
<strong>Aim of the work: </strong>to determine the role of Interleukin-10 (IL-10) polymorphism (rs 1800896) and Transforming Growth Factor-Beta-1(TGF-β1) polymorphism (509 CT) as markers for cirrhosis in Egyptian patients with chronic liver disease. <strong>Subjects and Methods:</strong> This case-control study was carried out on selected patients admitted to Tropical medicine department, Al Zahraa University Hospital during the period from March 2016 to April 2017. Genotyping of IL-10 (rs 1800896) and TGF-β1 (509 CT) polymorphisms were performed using real-time polymerase chain reaction (PCR) technique. <strong>Results:</strong> There was significant increase in IL10 and TGF β1 509 gene polymorphisms in compensated and de-compensated groups as compared to control group. <strong>Conclusion: </strong>Interleukin 10 rs 1800896 gene polymorphism and TGF β1 509 gene polymorphism are associated with risk of liver cirrhosis in patients with chronic hepatitis C virus infection. These findings could be useful for future screening for early detection of liver cirrhosis.
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584281
- DOI 10.12816/ejhm.2018.10282
- Views 117
- Downloads 0
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