Assessment of Serum Levels of Bone Metabolism Biomarkers in Sudanese with HIV Infection
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Bone metabolism disorders with increased fractures rate are common among HIV infected patients. This study was aimed to assess serum levels of bone metabolism biomarkers in Sudanese HIV infected patients. In a Hospital-based matched case control study conducted during the period from March 2014 to October 2014, blood specimen was collected from 50 individual with HIV infection and 30 healthy individuals and serum levels of bone metabolism biomarkers PTH, calcium , phosphorous and Alkaline phosphates activity was measured using spectrophotometrical methods. Data were collected using structural questionnaire. Data analysis was carried out by means of statistical package for social science (SPSS version 16). The mean level of PTH was significantly higher in HIV infected patients compared to healthy individuals (p value = 0.03). There were no significant differences in serum levels of calcium, phosphorous and Alkaline Phosphatase activity between HIV patients and healthy individuals (p value > 0.05). Serum level of phosphorous significant positively correlated with duration of HIV infection and negatively with age while other biomarkers did not correlate. HIV infection is associated with increased level of PTH. Keywords: HIV, Sudanese, bone metabolism biomarkers.
Authors and Affiliations
Haifa Mohamed Mahmoud, Reel Mohammed Mohammed, GadAllah Modawe, NassrEldin M. A. Shrif
Keywords
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