Assessment of Serum Lipid Profile in HIV-AIDS Patients Attending Sir Yahaya Memorial Hospital Birnin-Kebbi, Nigeria
Journal Title: Annual Research & Review in Biology - Year 2017, Vol 17, Issue 3
Abstract
Aims: To assess lipid profile among HIV patients on ART, ART-naïve patients and controls in our environment. Study Design: This is a cross-sectional study of 120 participants consisting of 40 HIV patients on ART, 40 ART-naïve patients and 40 negative controls. Place and Duration of Study: Antiretroviral Clinic, Sir Yahayya Memorial Hospital, Birnin-Kebbi and Chemical Pathology Department, Usmanu Danfodiyo University, Sokoto, between March, 2016 and June, 2016. Methodology: Serum total cholesterol, triglyceride and high-density lipoprotein-cholesterol (HDL-c) were assayed based on enzymatic methods using SELECTRA XL automated chemistry analyzer with analysis in batches. LDL-c and atherogenic index (AI) was calculated using Friedwald’s formula (LDL-c = TC-(TG/2.2)-HDL-c mmol/L) (Satya, 2011) and TC/HDL-c respectively. Results: Our result showed that the mean values of TC and HDLc was significantly higher (p<0.01) in HIV patients on ART compared to controls. The serum LDL-c was significantly lower (p<0.05) between patients on ART and controls. AI was significantly lower (p<0.01) in HIV patients on ART compared to controls. There was no statistically significant difference in TC and AI (P>0.05) between ART-naïve HIV-patients and controls. However, statistically significant difference was observed in BMl and LDL-c (P<0.05) in ART-naïve HIV-patients and controls. No statistically significant difference observed in the mean age, TG and LDL-c (P>0.05) between the patients on ART and ART-naïve patients. There was significant increase (P<0.05) in TC, HDL-c, AI and BMl in patients on ART compared to ART-naïve patients. Conclusions: Our findings indicated that HIV infected patients have a host of variations in their lipid profile compared to HIV negative controls in our environment. The dyslipidemia levels, high LDL-c and TG were found in patients compared to control. ART could have additional advantage of enhancing HDL-c and may be associated with reduced risk for cardiovascular events.
Authors and Affiliations
F. U. Bunza, I. Z. Wasagu
Keywords
Related Articles
- EP ID EP313513
- DOI 10.9734/ARRB/2017/35688
- Views 126
- Downloads 0
Current Status of Glossina Population Ecology
Background: Vector control remains the most visible method for large scale control of trypanosomiasis; there is a lack of suitable prophylactic drugs and vaccines against trypanosomiases and chemotherapeutic agents remai...
Proximate Composition, Vitamin and Anatomical Studies on Gomphrena celosioides
Gomphrena celosioides is an ornamental plant with highly medicinal values. Available information on its anatomical studies is scanty while proximate composition and vitamins investigations are lacking. This study therefo...
Osmotic Stress Effect on Different Cytological Characters of Roots and Growth Parameters in Different Wheat Species
Aims: To show how and why seedling growth parameters and different cytological characters of the roots of different wheat species may vary during osmotic stress conditions. To identify species that are tolerant to a lack...
Determination of Different Hormones Dose for Breeding of Green Back Mullet, Chelon subviridis
The study was conducted in the hatchery complex of Bangladesh Fisheries Research Institute, Brackishwater Station, Paikgacha, Khulna, Bangladesh. The body weights of collected male fishes were ranged from 42-50 g and tha...
Studies on Genetic Variability, Heritability and Genetic Advance in Onion (Allium cepa L.) Genotypes
The experimental material for the present investigation was comprised of 38 genotypes of onion. These genotypes were sown in Randomized Complete Block Design with three replications, to estimate the genetic variability,...