Assessment of Serum Lipid Profile in Patients of Coronary Artery Disease: A Case-Control Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 5
Abstract
Introduction: Coronary Heart Disease (CHD) is widely prevalent across the globe and significantly high level of Cholesterol in circulation is a single major risk factor associated with Coronary Heart Disease. It is well established that cardiovascular disease is associated with hypertension and elevated blood levels of low-density lipoprotein (LDL), total cholesterol, and triglycerides. In disparity, a low level of high density lipoprotein (HDL) is a risk factor for mortality from cardiovascular disease. The present study was conducted with the aim to assess the changes in the lipid profile of coronary heart disease patients. Material and Methods: The present study was done on 90 patients with acute or severe coronary heart diseases. Serum levels of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides were examined by using biochemical kits. Fasting samples of blood were collected both from cases and healthy controls and sent to the laboratory for processing and performance of the lipid profiles in batches. Lipid profiling included Total Serum Cholesterol (TSC), Low Density Lipoprotein-Cholesterol (LDLC), High Density Lipoprotein- Cholesterol (HDLC), and Triglycerides (TG). Results: The Total Serum Cholesterol to High density lipoprotein-Cholesterol and Low density lipoprotein- Cholesterol to High density lipoprotein-Cholesterol ratios also were significantly higher in cases than in controls, whereas the rise in Triglycerides to High Density Lipoprotein-Cholesterol ratio was not found to be significant. Conclusion: It was found that the total cholesterol, HDL cholesterol, LDL cholesterol and triglycerides concentrations were significantly higher (p < 0.05) in coronary heart disease patients.
Authors and Affiliations
Laltesh Kumar, Ajay Lal Das
Keywords
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