Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 6
Abstract
Introduction: The presence of symptoms, systolic dysfunction and Left Ventricle (LV) dilation are considered unfavourable prognostic markers in Aortic Valve Insufficiency (AVI). The role of diastolic dysfunction, which is considered unfavourable outcome marker in cardiac pathologies, is not well established in AVI. Aim: To evaluate if the presence of diastolic dysfunction may be associated with unfavourable prognostic markers in AVI patients. Materials and Methods: A cross-sectional prospective study was performed on 22 patients with moderate or severe AVI. They underwent clinical evaluation and transthoracic echocardiography. Associations between clinical, epidemiological and echocardiographic were evaluated by Student t-test for normally distributed variables or Mann-Whitney test for non-normal distribution. Comparison between proportions was performed by Chi-square test. Results: There was an association between increased LV filling pressure, assessed by E’ and E/E’ of Mitral Tissue Doppler, and impaired LV systolic function, respectively: R = 0.563, R2 = 0.281; p = 0.008 and R = 0.639, R2 = 0.378; p = 0.002. The LV indexed mass also was inversely associated with the LV ejection fraction (R = 0.62, R2 = 0.35 and p = 0.003). Conclusion: There was an association of LV diastolic dysfunction and ventricular hypertrophy with impaired left ventricle systolic function. Increased LV filling pressure and LV indexed mass should be considered in the management of AVI patients.
Authors and Affiliations
Meliza Goi Roscani, Juliana da Cunha Duarte, Gustavo Nicolodi Augusto, Thaysa Rodrigues de Moraes Salgueiro, Mariana N Meireles, Katashi Okoshi, João Carlos Hueb
Prosthetic Rehabilitation of a Large Frontal Cranial Defect-A Case Report
ABSTRACT With an increased incidence of automobile accidents, head injuries in road traffic accident victims are common. In order to salvage the vital intra-cranial structures from the effects of trauma, emergency attent...
A Rare Case of Successfully Treated Coombs Negative Immune Haemolytic Anaemia in Pregnancy
Immune haemolytic anaemia in pregnancy, although rare, but it can be life threatening. Severe anaemia with jaundice, unresponsive to blood transfusion can clinch the diagnosis of immune haemolytic anaemia. Our patient wa...
Significance of Cytological Diagnosis in Benign Salivary Gland Lesion
ABSTRACT A diffuse, chronic, non-inflammatory, non-neoplastic usually bilateral, enlargement of major salivary glands is termed as Sialadenosis or sialosis. It is an uncommon cause for enlargement of the parotid gland. W...
Evaluation of HiaureusTM Coagulase Confirmation Kit in Identification of Staphylococcus aureus
Introduction: Staphylococcus aureus is a facultative anaerobic Gram positive coccal bacterium whose incidence ranges to different infections. It is a cause of various uncomplicated skin infections, abscesses, septicaemia...
Molecular Strain Typing of Clinical Isolates, Trichophyton rubrum using Non Transcribed Spacer (NTS) Region as a Molecular Marker
Introduction: Dermatophytes are a group of fungi which infect keratinized tissues and causes superficial mycoses in humans and animals. The group comprises of three major genera, Trichophyton, Microsporum and Epidermophy...