Association Between Left Ventricle Diastolic Dysfunction and Unfavorable Prognostic Markers in Patients with Aortic Insufficiency
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 6
Abstract
Introduction: The presence of symptoms, systolic dysfunction and Left Ventricle (LV) dilation are considered unfavourable prognostic markers in Aortic Valve Insufficiency (AVI). The role of diastolic dysfunction, which is considered unfavourable outcome marker in cardiac pathologies, is not well established in AVI. Aim: To evaluate if the presence of diastolic dysfunction may be associated with unfavourable prognostic markers in AVI patients. Materials and Methods: A cross-sectional prospective study was performed on 22 patients with moderate or severe AVI. They underwent clinical evaluation and transthoracic echocardiography. Associations between clinical, epidemiological and echocardiographic were evaluated by Student t-test for normally distributed variables or Mann-Whitney test for non-normal distribution. Comparison between proportions was performed by Chi-square test. Results: There was an association between increased LV filling pressure, assessed by E’ and E/E’ of Mitral Tissue Doppler, and impaired LV systolic function, respectively: R = 0.563, R2 = 0.281; p = 0.008 and R = 0.639, R2 = 0.378; p = 0.002. The LV indexed mass also was inversely associated with the LV ejection fraction (R = 0.62, R2 = 0.35 and p = 0.003). Conclusion: There was an association of LV diastolic dysfunction and ventricular hypertrophy with impaired left ventricle systolic function. Increased LV filling pressure and LV indexed mass should be considered in the management of AVI patients.
Authors and Affiliations
Meliza Goi Roscani, Juliana da Cunha Duarte, Gustavo Nicolodi Augusto, Thaysa Rodrigues de Moraes Salgueiro, Mariana N Meireles, Katashi Okoshi, João Carlos Hueb
Keywords
Related Articles
- EP ID EP349050
- DOI 10.7860/JCDR/2017/23463.9974
- Views 85
- Downloads 0
Evaluation of Analgesic Activity of Standardised Aqueous Extract of Withania somnifera in Healthy Human Volunteers using Mechanical Pain Model
ABSTRACT Introduction: Drugs commonly used for pain management are associated with adverse effects. Experimental pain models in human healthy volunteers are advantageous for early evaluation of analgesics. Studies with W...
Immunohistochemical Analysis of Natural Killer Cells and CD8+ T Lymphocytes in Lower Lip Squamous Cell Carcinoma
Introduction: Inflammatory cells may influence the growth of malignant neoplasms through pro and anti-tumour effects. Natural Killer (NK) cells and cytotoxic T lymphocytes (CD8+) are the main effector cells against cance...
Prenatal Screening for Rare Co-Inheritance of HbE and β-Thalassaemia Traits in Western India
The mutations in Haemoglobin Beta (HBB) gene, bring about less or no production of Hb β-chain synthesis in affected cases, leading from minor to major types depending on haematological indices. In compound heterozygotic...
Effectiveness of Two Techniques in Removal of Calcium Hydroxide Medicament from Root Canals: An in-vitro Assessment
Introduction: Calcium Hydroxide {Ca(OH)2} is widely used as intracanal medicament. However, complete removal of Ca(OH)2 is very difficult from canal walls resulting in its residues on canal wall which interfere with bond...
Can Unilateral Pityriasis Rosea be Considered a Form of Superimposed Lateralized Exanthem?
Letter to Editor