Association of Alpha-1-Antitrypsin with Asthma
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Asthma is a chronic inflammatory disease of the airways that affects people of all ages. Alpha-1-antitrypsin (or alpha-1-proteinase inhibitor) is the most abundant circulating proteinase inhibitor. Alpha-1-antitrypsin deficiency has a high morbidity and mortality. Alpha-1-antitrypsin deficiency may present with symptoms that are similar to those of asthma. Aim of the present study was to determine the level of alpha- 1-antitrypsin activity in case of asthma patients to assess the possibility of misdiagnosis which leads to increase morbidity. Material and Methods: The present study included the patients diagnosed with asthma in the department of T.B. and Respiratory Diseases in a span of one year. Blood samples of Patients between age group of 31 to 65 years were collected and analyzed for alpha-1-antitrypsin activity for the present study. The method that was adopted in the present study of serum alpha-1-antitrypsin activity was by measuring the inhibition of trypsin by serum. Results: The serum alpha-1-antitrypsin level was found to be 2.37 + 0.13 mg/ml among the control group, which lies in the normal range. The range of serum alpha-1-antitrypsin activity of the control group is 2 to 2.56 mg/ml. The serum alpha-1-antitrypsin level was found to be 2.26 + 0.36 mg/ml among the sixty asthma patients. Amongst them six patients had alpha-1-antitrypsin less than 2 mg/ml. The range of serum alpha-1-antitrypsin activity of the asthmatic patients was 0.94 to 2.67 mg/ml. Conclusion: Early diagnosis by screening of all asthmatic patients as well as family members of confirmed alpha-1- antitrypsin deficiency cases is needed to decrease incidence of morbidity and mortality in affected individuals
Authors and Affiliations
Humera Khan, Khushtar Anwar Salman
Keywords
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