Association of Alpha-1-Antitrypsin with Asthma
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Asthma is a chronic inflammatory disease of the airways that affects people of all ages. Alpha-1-antitrypsin (or alpha-1-proteinase inhibitor) is the most abundant circulating proteinase inhibitor. Alpha-1-antitrypsin deficiency has a high morbidity and mortality. Alpha-1-antitrypsin deficiency may present with symptoms that are similar to those of asthma. Aim of the present study was to determine the level of alpha- 1-antitrypsin activity in case of asthma patients to assess the possibility of misdiagnosis which leads to increase morbidity. Material and Methods: The present study included the patients diagnosed with asthma in the department of T.B. and Respiratory Diseases in a span of one year. Blood samples of Patients between age group of 31 to 65 years were collected and analyzed for alpha-1-antitrypsin activity for the present study. The method that was adopted in the present study of serum alpha-1-antitrypsin activity was by measuring the inhibition of trypsin by serum. Results: The serum alpha-1-antitrypsin level was found to be 2.37 + 0.13 mg/ml among the control group, which lies in the normal range. The range of serum alpha-1-antitrypsin activity of the control group is 2 to 2.56 mg/ml. The serum alpha-1-antitrypsin level was found to be 2.26 + 0.36 mg/ml among the sixty asthma patients. Amongst them six patients had alpha-1-antitrypsin less than 2 mg/ml. The range of serum alpha-1-antitrypsin activity of the asthmatic patients was 0.94 to 2.67 mg/ml. Conclusion: Early diagnosis by screening of all asthmatic patients as well as family members of confirmed alpha-1- antitrypsin deficiency cases is needed to decrease incidence of morbidity and mortality in affected individuals
Authors and Affiliations
Humera Khan, Khushtar Anwar Salman
Keywords
Related Articles
- EP ID EP430004
- DOI -
- Views 143
- Downloads 0
Prospective Analysis of Psycho Social and Surgical Outcome of Breast Reconstruction Following Mastectomy
Introduction: Breast reconstruction (BR) plays a significant role in the woman’s physical, emotional and psychological recovery from breast cancer. The presence of a woman with a lack of her breast leads to psychological...
A Study on Clinico Pathological Spectrum of Nephrotic Syndrome in Adult Patients in a Teaching Hospital in Eastern India
Introduction: Nephrotic Syndrome is one of the important causes of end stage renal diseases in adult patients worldwide. Current research aimed to study prospectively the clinicopathological spectrum of glomerular diseas...
Towards a better Diagnosis of Prostate Cancer: A Review of Prostate Cancer Screening Tests
Being one of the commonest cancers amongst males, better diagnostic or screening techniques can prevent lot of mortality and morbidity. Prostate cancer is one of the few cancers with better outcome if diagnosed early. Al...
Special Stains to Disclose Barr Bodies in Buccal Scrape for Gender Determination in Forensic Science
Introduction: Sex determination holds a valuable significance in these circumstances to clear medico-legal problems. In some instances the sample available might be very minute, in the form of only few cells which can be...
Clinically Relevant Drug Interactions Associated with the Use of Analgesics in Dentistry
An increasing number of patients on polypharmacy present to the dentist today for treatment. Analgesics are frequently prescribed. In addition to this, patients may also be taking over-the-counter medications for various...