Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis
Journal Title: Міжнародний ендокринологічний журнал - Year 2016, Vol 2, Issue 74
Abstract
The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis was investigated. Significant increase by 33.1 % (P = 0.01) of desquamated endothelial cells number in the blood was found in patients with T-allele compared with that of in GG-genotype carriers. Also, the concentration of total nitric oxide stable metabolites was 10.4 % (P = 0.04) higher and the level of nitrate anions in the blood was 10.8 % (P = 0.02) higher than in comparison group. Among patients with hypothyroidism and concomitant chronic cholecystitis, the content of vascular endothelial growth factor was 27.7 % (P = 0.03) higher in T-allele carriers as compared with patients with GG-genotype.
Authors and Affiliations
I. V. Prysiazhniuk, N. V. Pashkovska
Keywords
Related Articles
- EP ID EP206839
- DOI -
- Views 64
- Downloads 0
Girls Precocious Sexual Development: Capability of Laboratory Diagnosis
The importance of timely detection of the causes of precocious sexual development is associated, firstly, with the possible existence of tumor, as well as with the states accompanied by the accelerated puberty. Key role...
Parameters of thyroid homeostasis in patients with hepatitis of non-viral etiology
Background. The purpose of this study was to assess thyroid homeostasis in patients with chronic hepatitis of non-viral etiology and to analyze the correlation between serum thyroid parameters and A/C polymorphism of the...
The Functional Status of Hypophysis — Gonad Axis in Patients with Polycystic Ovary Syndrome
Background. The polycystic ovary syndrome (PCOS) is the most frequent form of endocrine pathology and occurs in 5–10 % women of reproductive age and makes up 80 %, and according to some data, even 90 % of all forms of hy...
Lifestyle modification and dietary nutrition in patients with arterial hypertension and diabetes mellitus: recommendations of European consensus and the facts of life (literature review)
The review presents data from foreign and the national literature, world consensus recommendations 2016–2018 on the features of lifestyle modification, correction of alcohol consumption, smoking cessation, increased phys...
Clinical and Hormonal Characteristics of Patients with Giant Masses of Sellar-Chiasmatic Region
Objective: to study the clinical and hormonal characteristics of patients with giant masses of sellar-chiasmatic area. Material and methods. During the period from 2015 to 2016, we have examined 35 adult patients with pi...