Association of Glucose-6-phosphate dehydrogenase deficiency and hyperbilirubinemia in neonates
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 9
Abstract
Background & objective – Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most important disease of hexose monophosphate pathway. It is an X-linked recessive disease, where the deficiency of the enzyme causes a spectrum of clinical manifestations. The aim of this study was to see the occurrence of G6PD deficiency in neonates and its association with hyperbilirubinemia. Materials & Methods – This retrospective study was carried out in a tertiary care centre between January to September 2016. Neonates of both gender with G6PD deficiency and normal G6PD having hyperbilirubinemia (TSB >5mg/dl) were included. Results – Out of 300 neonates with hyperbilirubinemia, 44% were Glucose-6-phosphate dehydrogenase deficient. Male:female (M:F) ratio of G6PD deficient neonates was 1.6:1. Majority of G6PD deficient neonates had TSB>15 mg/dl; whereas G6PD non-deficient had mostly hyperbilirubinemia at TSB levels <15mg/dl (66.1%). Mean Total serum bilirubin (TSB) in G6PD deficient neonates were more as compared to normal G6PD icteric neonates and was statistically significant (P<0.05). Conclusion – In G6PD deficient neonates’ hyperbilirubinemia is very severe type which may be a risk factor for neurological complications like kernicterus. Therefore, implementation of National control program for screening of G6PD deficiency in neonates will reduce the complications and fatal conditions arising due to this inborn blood disorder.
Authors and Affiliations
Rumi Deori, Snehankar Kalita, Swarnali Devi Baruah
Keywords
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- EP ID EP381932
- DOI 10.9790/0853-1709033035.
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