Association of Insulin Resistance and Selected Adipokines in Cardiovascular Disease with and without Metabolic Syndrome
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
Adipose tissue produces several bioactive mediators’ adipokines which influence insulin resistance, diabetes, body-weight homeostasis and inflammation. Plasma adiponectin and leptin are closely related to insulin sensitivity. In present study we measured adipokines, lipid profile, and insulin resistance in CVD patients with and without MetS. 100 patients with cardiovascular disease and 50 healthy persons as control subjects were included. Adiponectin, leptin, lipid profiles, glucose, and insulin levels were measured and insulin resistance was computed by the HOMA. Patients (n=100) and control subjects (n=50) were matched for age, BMI, WC and blood pressure category systolic and diastolic, all were (P<0.0001) highly significant. CVD Savita Rathore, Anil Bidwai JMSCR Volume 2 Issue 5 May 2014 Page 1177 JMSCR Volume||2||Issue||5||Pages 1176-1186||May 2014 2014 patients with and without MetS had highly elevated TC, LDL-C, VLDL-C cholesterol and TG and lower HDLC level than the control subjects, all were P<0.0001. Glucose, insulin and insulin resistance were also significantly increased in both patient groups than control subjects. Leptin level was higher and adiponectin was significantly lower in patients with MetS and without Mets compared with control subjects, (P<0.0001). We summarized that the measurement of adiponectin and leptin may have a beneficial in the treatment and prevention of cardiovascular diseases in the future.
Authors and Affiliations
Savita Rathore
Keywords
Related Articles
- EP ID EP205919
- DOI -
- Views 90
- Downloads 0
Intra Medullary Tuberculoma Presenting as Brown Sequard Syndrome with Concurrent Intradural Extramedullary Tuberculoma and Arachnoiditis
Intramedullary and intradural-extramedullary spinal tuberculomas causing spinal cord compression is an uncommon entity. We report an unique case of a 27-year-old Indian male patient on 4 drug antituberculous chemotherapy...
Induction Characteristics of Propofol and Thiopentone: A Comparative Clinical Study in short day Care Cases
In This Randomized Study, an attempt was made to evaluate clinically and compare Propofol and Thiopentone when used alone in unpremedicated patients undergoing minor surgical and orthopedic procedures like fracture reduc...
Alexia without Agraphia Following an Ischaemic Stroke in a 70 Year Old Nigerian African
Pure alexia is an acquired reading disorder, in previously literate subjects who show correct writing (spontaneously or on dictation) and normal oral spelling in the absence of apraxia, dementia or visual agnosia. It is...
Risk Factors in Recurrence of Amblyopia after Successful Occlusion Therapy
Context: Recurrence after successful treatment of amblyopia is known and understanding the risk factors could help effective management. Aim: To measure incidence of recurrence in successfully treated cases of anisometro...
Study to Determine Relapse and Mortality Rates in Tuberculosis Cases and their Epidemiological Correlates: A Historical Cohort Study
Background: India is the country with the highest burden of TB. The World Health Organization (WHO) statistics for 2015 give an estimated incidence figure of 2.2 million cases of TB for India out of a global incidence of...