Association of Insulin Resistance and Selected Adipokines in Cardiovascular Disease with and without Metabolic Syndrome
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 5
Abstract
Adipose tissue produces several bioactive mediators’ adipokines which influence insulin resistance, diabetes, body-weight homeostasis and inflammation. Plasma adiponectin and leptin are closely related to insulin sensitivity. In present study we measured adipokines, lipid profile, and insulin resistance in CVD patients with and without MetS. 100 patients with cardiovascular disease and 50 healthy persons as control subjects were included. Adiponectin, leptin, lipid profiles, glucose, and insulin levels were measured and insulin resistance was computed by the HOMA. Patients (n=100) and control subjects (n=50) were matched for age, BMI, WC and blood pressure category systolic and diastolic, all were (P<0.0001) highly significant. CVD Savita Rathore, Anil Bidwai JMSCR Volume 2 Issue 5 May 2014 Page 1177 JMSCR Volume||2||Issue||5||Pages 1176-1186||May 2014 2014 patients with and without MetS had highly elevated TC, LDL-C, VLDL-C cholesterol and TG and lower HDLC level than the control subjects, all were P<0.0001. Glucose, insulin and insulin resistance were also significantly increased in both patient groups than control subjects. Leptin level was higher and adiponectin was significantly lower in patients with MetS and without Mets compared with control subjects, (P<0.0001). We summarized that the measurement of adiponectin and leptin may have a beneficial in the treatment and prevention of cardiovascular diseases in the future.
Authors and Affiliations
Savita Rathore
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