Association of Maternal Vitamin C Status with Gestational Diabetes Mellitus
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2015, Vol 4, Issue 3
Abstract
Background: The role of antioxidants in the etiology of gestational diabetes mellitus (GDM) has been given limited attention. Vitamin C is a nutrient with radical quenching property and has been claimed to influence glucose tolerance. Aim: To study the association between vitamin C status (dietary intake and plasma concentrations) and GDM. Material and Methods: Using a case-control design with 1:3 ratio we examined 42 pregnant women with GDM and 158 normal glucose tolerant (NGT) gestational age-matched healthy pregnant women at an average of 26 weeks of gestation. Maternal vitamin C intake was determined using detailed semi food frequency questionnaire (SFFQ) and 24 hour diet recall. Plasma vitamin C was determined using a spectrophotometric method in non-fasting samples. GDM was diagnosed by 75 gm oral glucose tolerance test (OGTT) using International Association for Diabetes in Pregnancy Study Group (IADPSG) criteria (fasting ≥92mg%, 1hour ≥180mg%, 2 hour ≥153mg %). Results: GDM women had lower median intake of vitamin C (35.0 mg/day vs. 66.7; p<0.001) and lower median plasma vitamin C concentration (45.9 µmol/L vs. 95.2; p<0.001) compared to NGT women. Plasma vitamin C concentration was inversely related to fasting, 1 hour and 2 hour post glucose plasma glucose concentrations (p<0.001). The associations remained significant after adjustment for age, income, pre-pregnancy BMI, and stress. Conclusion: Our findings suggest that low vitamin C intake as well as low plasma vitamin C concentration is associated with GDM. This association needs to be tested in a large prospective study and subsequently in a clinical trial.
Authors and Affiliations
Hedyeh Masoodi , Trupti Vilas Kamat , Kurus Jhangir Coyaji , Dattatray Shivram Bhat , Kalyanaraman Kumaran , Chitaranjan Sakerlal Yajnik
Keywords
Related Articles
- EP ID EP127460
- DOI -
- Views 96
- Downloads 0
Immunohistochemistry of Epithelioid Soft Tissue Sarcomas, Literature Review Based on Case Studies
Neoplasms with epithelioid histology may be diagnostically challenging. Immunohistochemistry (IHC) can aid in confirming the differential diagnosis of mesotheliomas, melanomas, lymphomas, and soft tissue sarcomas, all tu...
Susceptibility, Resistance and Treatment Strategy for Infections Caused by Viridans Group Streptococci - A Review
Viridans Group Streptococci (VGS) were considered to be commensal organisms of low virulence. Their major disease associations were formerly limited to dental caries and infective endocarditis. Over the last several year...
Substandard, Spurious, Falsely-Labelled, Falsified and Counterfeit (SSFFC) Drugs: Time to Take a Bitter Pill
Substandard, Spurious, Falsely-Labelled, Falsified and Counterfeit (SSFFC) drugs are an emerging public health concern in India. With one of the huge pharmaceutical sectors in the world, India has a varied prevalence of...
An Aberrant Artery Arising From Common Hepatic Artery
Common hepatic artery is the branch of celiac trunk which is chief artery of the foregut. Branches of celiac trunk supply the gastrointestinal tract and its associated glands which are derived from foregut. Anatomy and v...
Therapeutic Potential of Human Bone Marrow Derived Mesenchymal Stromal Cells in Combination with Silymarin against Carbon Tetrachloride Induced Liver Cirrhosis in Wistar Rats
Background: Self-renewal, active proliferation in vitro, abundant sources for isolation, and a high differentiation capacity, make mesenchymal stem cells to be potentially therapeutic for liver cirrhosis. Aim and Objecti...