Association of Plasma Level of Thiobarbituric Acid Reactive Substances with Extent of Hepatocellular Injury in Preterm Infants with Cholestatic Jaundice
Journal Title: Indian Journal of Clinical Biochemistry - Year 2006, Vol 21, Issue 2
Abstract
The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (2 mg/dl) (n = 25) or in the control group (n = 16). Blood samples for measurement of TBARS, direct bilirubin and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92; P
Authors and Affiliations
M Maneesh, Bhumika Upadhya, R Bhutia
Keywords
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