Association of Serum Apolipoprotein in Patients with Coronary Heart Disease – An Observational Study
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2014, Vol 11, Issue 1
Abstract
Introduction: Incidence of coronary heart disease (CHD) has shown an upward trend in Indian in the last decade. Estimation of serum lipids like Cholesterol and triglycerides were used to assess the risk of CHD. However, the correlation between serum Cholesterol and CHD is not ideal. Apoplipoprotein play an important role in many disorders of lipid metabolism. Indeed, it has become increasingly clear that while the lipids in lipoproteins are the transported moieties, the protein moieties of lipoproteins - the apoproteins - perform the crucial roles of transporting the lipids, and apoproteins can determine the levels of lipoprotein lipids. Therefore, attempts have been made to assess the relationships between plasma apoprotein concentrations and CHD. Aim and Objectives: To see the association of serum apolipoprotein A-I and B in patient with Coronary Heart Disease. Materials and Methods: The present study was conducted at Government Medical College and Hospital, Aurangabad. Levels of Apolipoprotein A-I and B in 60 Coronary Heart Disease patients admitted with first episode of coronary heart disease in ICCU were compared with 60 healthy apparently normal age, sex matched individuals. Results: it was observed that levels of apolipoprotein A-I and the ratio of apolipoprotein A-1 and B were decreased in CHD patients where as levels of apolipoprotein B was increased in CHD patients as compared to control group. And the difference was also statistically significant. Conclusion: concentration of apo A-I, apo B and its ratio can be a useful summary index of risk of CHD.
Authors and Affiliations
Deepak Kishan Bokankar , Kedar Balwant Joshi , Patil V. P
Keywords
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