Association of serum leptin and diastolic blood pressure in pre-eclamptic women
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 10, Issue 2
Abstract
Background: Maternal peripheral leptin levels are enhanced during normal pregnancy and collectively suggest that leptin concentrations peak in the second trimester. A better understanding of leptin and its role in PE may eventually impact those causes of human perinatal morbidity and mortality.Aim: To find out the association of serum leptin and diastolic blood pressure in pre-eclamptic women.Material and Methods: This hospital-based case control study involved 40 normal pregnant and 40 pre-eclamptic women. Serum leptin was estimated by Enzyme immunoassay for quantitative determination of Human Leptin in serum. The serum leptin levels were correlated with diastolic blood pressure.Results: Mean serum leptin concentration was significantly higher in PE women compared to controls 28.85±7.2 ng/ml vs. 24.80±6.5 ng/ml. A significant positive correlation (r =0.6, p <0.0001) was observed between serum leptin and diastolic blood pressure in pre-eclampstic women.Conclusion: Leptin levels were significantly elevated in PE than in normal pregnant women. Serum leptin was also positively correlated with blood pressure.
Authors and Affiliations
NDheebalakshmi . , VRajagopal .
Keywords
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- EP ID EP613233
- DOI 10.26611/10021023
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