Association of Serum Vascular Endothelial Growth Factor (VEGF) Levels with Nonalcoholic Fatty Liver Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Background.Nonalcoholic fatty liver disease (NAFLD) is a growing problem due to the epidemic of obesity. Although the pathogenesis of NAFLD is still not fully understood, some studies suggested that angiogenesismight play a role in its progression. Vascular endothelial growth factor (VEGF) is a main proangiogenic factor implicated in angiogenesis. Aim. To asses the significance of serum VEGF levelsin NAFLD patients. Methods. Cross-sectional study of 40 consecutive NAFLD patients and 40 healthy controls who came to Adam Malik General Hospital Medanbetween May 2018 and July 2018 were included. The NAFLD diagnosis required evidence of hepatic steatosis on ultrasound and exclusion of other causes of liver injury. Serum VEGF levels were determined by an enzyme immunoassayQuantikine Human VEGF-ELISA kit. Univariate analyses, bivariate analyses(T independent test and MannWhitney test) with SPSS version 22. Statistical significant if p< 0,05.Results. From a total of 40 patients, 18 patients (45%) were men with an average age of 44,6 years. Serum VEGF levels were significantly higher in NAFLDpatients compared to healthy controls (315,8pg/mL vs 214,75 pg/mL, p= 0,002). Levels of AST, ALT, fasting blood glucose, total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol were significant difference between NAFLD patients and healthy controls(p<0,001). There were no significant difference of serum VEGF levels in NAFLD patients based on age, sex and Body Mass Index (BMI). Conclusion. Our result showed that serum VEGF levels significant higher in NAFLD patients. This suggest that angiogenesis could play an important role in the pathogenesis of NAFLD.
Authors and Affiliations
Mariati Gurning, GontarAlamsyah Siregar, Masrul Lubis
Keywords
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- EP ID EP444191
- DOI 10.9790/0853-1801133640.
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