Association of single nucleotide polymorphism in the calpain/calpastatin system genes with quantitative traits of Aberdeen-Angus
Journal Title: Біологія тварин - Year 2017, Vol 19, Issue 1
Abstract
Pleiotropic effect of calpain/calpastatin system genes influences both animal’s quantitative traits and qualitative characteristics of muscle tissue. The study is aimed to evaluate the association of single nucleotide polymorphisms CAPN316 and CAST282 in calpain and calpastatin genes with quantitative traits — the body weight dynamics. The body weight dynamics from birth until 5 years of age was evaluated in Aberdeen-Angus cows (n=73) in Kharkiv region. Molecular genetic analysis was performed by PCR-RFLP. Distributions was analyzed with χ² criterion, ANOVA was used for multiple comparisons. The influence of individual factor was evaluated by Snedecor (h2). Differences between Aberdeen Angus groups was studied by Nei’s standard genetic distances. Allele frequencies of SNP CAPN316 are C=0.404 and G=0.586, of SNP CAST282 are C=0.788 and G=0.212. The genotypic distributions were in agreement with the Hardy-Weinberg equilibrium. There were significant impact of CAPN316 CC genotype on body weight at the age of three (F=3.57; h2=46%) and four years (F=3.70; h2=47%) and CAST282 CG genotype on body weight at the age of 15 months (F=3.29; h2=43%). Effect of calpain and calpastatin genes C-alleles on weight gain increases after the age of two years, when the expression of genes regulating growth and development processes at an early age is reduced. Animal selection at the age of two years aimed to the meat quality improvement is unlikely to lead to significant body weight decrease.
Authors and Affiliations
S. Ruban, O. M. Fedota, N. Lysenko, A. Kolіsnik, I. Goraichuk, L. Ponko
Keywords
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- DOI 10.15407/animbiol19.01.100
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